Antigen-specific CD4 T cell analyses
CD4+ T cells play an important role in the efficiency of vaccines, cancer immunotherapy or other immunomodulating therapies. By obtaining information on the type and functionality of T helper cells in cellular assays we can identify the magnitude and type of immune response that has been or will be elicited by your treatment.
CD4+ T cells, alias T helper cells, mediate the immune response by cell-cell interaction with other immune cells, such as CD40-CD40L on antigen-presenting cells, and through secretion of cytokines. These T helper cell reactions are particularly important for B cell responses and the accompanying antibody production. One can discriminate different types of T helper cells: T helper 1 (Th1), T helper 2 (Th2), T helper 17 (Th17), T regulatory (T reg) and follicular helper T (Tfh) cells. All types of T helper cells have their own role and importance; they affect different immune cells and consequently result in another immune response.
What can Sanquin do for you?
Sanquin can help you identify the T helper cell responses that have been developed in response to your treatment. This knowledge can be useful in, for example, vaccine responses in clinical trials, but also for drug safety studies in clinical trials evaluating new biologics.