Super antigens such as SEB activate lymphocytes. Test your compound's immunomodulatory capacity by analyzing effects in a super antigen assay.
Effects of immunomodulatory compounds on lymphocytes can be investigated in cultures in which lymphocytes are stimulated by superantigens. Superantigens can be used to increase the number of responsive lymphocytes. By using suboptimal concentrations of superantigen such as SEB, inhibition or stimulation of proliferation/cytokine production by the studied compound can be determined easily.
Depending on your wishes we can either repeatedly use the same donor samples or numerous different donors.
PBMCs of donor will be stimulated with SEB in presence or absence of compound(s) of interest.