Available kits and services

We have developed reliable assays to measure concentrations in patients' samples

Read here whether it is more convenient for you to use our test service or to buy an ELISA kit to perform the test in your own laboratory or contact us to discuss the best options to meet your goals. 

You can ship your samples cold, rather than with dry ice, reducing your shipment costs. Read more on accurate measurement of biologics PharmacoKinetics and Anti Drug Antibodies with cold shipments.

 

 

TNF inhibitors | Available kits and services

  • Adalimumab

    Adalimumab is a tumor necrosis factor (TNF) inhibitor that can diminish inflammation. It is a fully human monoclonal antibody. 

    Read more about adalimumab.
    Contact us to order the level or ADA kit.
    To use our drug level and ADA testing services, fill out this form.

  • Infliximab

    Infliximab is a tumor necrosis factor (TNF) inhibitor that can diminish inflammation. It is a chimeric human/mouse monoclonal antibody.

    Read more about Infliximab.
    Contact us to order the level or ADA kit.
    To use our drug level and ADA testing services, fill out this form.

     

  • Etanercept

    Etanercept competitively inhibits TNF binding to its cell surface receptors, thereby inhibiting the biological activity of TNF.

    Read more about etanercept.
    Request form service testing

  • Certolizumab

    Certolizumab binds with high affinity to human TNFα, thereby neutralizing this pro-inflammatory cytokine, which can relieve signs and symptoms in patients with inflammatory conditions. 

    Read more about certolizumab.
    To use our drug level and ADA testing services, fill out this form.

  • Golimumab

    Golimumab inhibits the inflammatory response by preventing the interaction of TNF-α with its receptors. 

    Read more about golimumab.
    To use our drug level and ADA testing services, fill out this form.

B-cell and T-cell inhibitors | Available services

  • Vedolizumab

    Vedolizumab is a monoclonal antibody directed at α4β7 integrin, that reduces inflammation specifically in the gut

    Read more about vedolizumab.
    To use our drug level and ADA testing services, fill out this form.

  • Rituximab

    Rituximab is a monoclonal antibody directed against CD20 protein present on B‑lymphocytes. Rituximab is used to treat various blood cancers and inflammatory conditions.

    Read more about rituximab.
    To use our drug level and ADA testing services, fill out this form.

  • Natalizumab

    Natalizumab inhibits adhesion-molecule via binding to α4β1 integrin, and is thought to prevent migration of inflammatory cells into the brain in multiple sclerosis. 

    Read more about natalizumab.
    To use our drug level and ADA testing services, fill out this form.

  • Abatacept

    Abatacept modulates a key costimulatory signal required for full activation of T lymphocytes expressing CD28, thereby dampening T lymphocyte-dependent antibody responses and inflammation.

    Read more about abatacept.
    To use our drug level testing services, fill out this form.

Cytokine inhibitors | Available services

  • Ustekinumab

    Ustekinumab is a fully human IgG1κ monoclonal antibody that targets both interleukin-12 and interleukin-23.

    Read more about ustekinumab.
    To use our drug level and ADA testing services, fill out this form.

  • Tocilizumab

    Tocilizumab is a humanised IgG1 monoclonal antibody directed against the receptor of the human pro-inflammatory cytokine IL-6.

    Read more about tocilizumab.
    To use our drug level and ADA testing services, fill out this form.

Other effector mechanisms | Available services

  • Complement C5 inhibitor | eculizumab

    Eculizumab is a humanised monoclonal antibody that targets human C5 complement protein and inhibits the activation of terminal complement. 

    Read more about eculizumab.
    To use our level testing services, email us at biologics@sanquin.nl.

  • Glycoprotein IIb/IIIa receptor antagonist | abciximab

    Abciximab is a glycoprotein IIb/IIIa receptor antagonist that acts as a platelet aggregation inhibitor. It is used to prevent thrombus formation during coronary artery procedures. Anti-drug-antibodies may form upon treatment with abciximab.


     

  • HER2 inhibitor | trastuzumab

    Trastuzumab is a recombinant humanised IgG1 monoclonal antibody against the human epidermal growth factor receptor 2 (HER2), which is overexpressed in about 20-30% of primary breast cancers.

    Read more about trastuzumab.
    To use our drug level and ADA testing services, fill out this form.

  • IgE inhibitor | omalizumab level test

    Omalizumab prevents binding of IgE to the high-affinity IgE receptor (FcRI), and thereby reduces the amount of free IgE that is available to trigger the allergic cascade

    Read more about omalizumab.
    To use our drug level and ADA testing services, fill out this form.

  • PD1 inhibitor | nivolumab level test

    Nivolumab is a human monoclonal antibody directed at PD-1 receptor, a negative regulator of T-cell activity. Nivolumab potentiates T-cell responses, including anti-tumour responses.

    Read more about nivolumab.
    To use our drug level and ADA testing services, fill out this form.