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Available services

Our reliable assays to measure concentrations in patients' samples are uniquely imbedded within literature

To support Therapeutic Drug Monitoring for biologics, Sanquin Diagnostic Services now offers the possibility to determine the biologic level remotely via finger prick as well, contact us to discuss the best options to meet your goals!

Browse the extinsive list of literature references using our services and kits.

Is your biologic not listed below? Contact [email protected] to discuss the potential for rapid development of a new assay.

TNF inhibitors | Available services

  • Adalimumab

    Adalimumab is a tumor necrosis factor (TNF) inhibitor that can diminish inflammation. It is a fully human monoclonal antibody. 

    Read more about adalimumab.

    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

  • Certolizumab

    Certolizumab binds with high affinity to human TNFα, thereby neutralizing this pro-inflammatory cytokine, which can relieve signs and symptoms in patients with inflammatory conditions. 

    Read more about certolizumab.

    To use our drug level testing services, fill out this form.

    To use our ADA testing services, email us at [email protected]

    To use our drug level testing services via remote collected finger prick, fill out this form.

  • Etanercept

    Etanercept competitively inhibits TNF binding to its cell surface receptors, thereby inhibiting the biological activity of TNF.

    Read more about etanercept.

    To use our drug level testing services, fill out this form.

  • Golimumab

    Golimumab inhibits the inflammatory response by preventing the interaction of TNF-α with its receptors. 

    Read more about golimumab.

    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

  • Infliximab

    Infliximab is a tumor necrosis factor (TNF) inhibitor that can diminish inflammation. It is a chimeric human/mouse monoclonal antibody.

    Read more about Infliximab.

    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

Cytokine inhibitors | Available services

  • Brodalumab

    Brodalumab is a human monoclonal antibody directed against the pro-inflammatory interleukin 17 receptor (IL17R). Brodalumab is being used in the treatment of moderate to severe psoriasis.

    Read more about brodalumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Canakinumab

    Canakinumab is a human monoclonal antibody directed against interleukin 1 beta (IL1B). Canakinumab is being used in the treatment of of cryopyrin-associated periodic syndromes (CAPS).

    Read more about canakinumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Dupilumab

    Dupilumab is a human monoclonal antibody directed against interleukin 4 receptor alpha (IL4RA). Dupilumab is being used in the treatment of moderate-to-severe atopic dermatitis and for asthma.

    Read more about dupilumab.

    To use our drug level testing services, fill out this form.

    To use our drug level testing services via remote collected finger prick, fill out this form.

  • Guselkumab

    Guselkumab is a human monoclonal antibody directed against interleukin 23 (IL23). Guselkumab is being used in the treatment of plaque psoriasis.

    Read more about guselkumab.

    Enquire about our validated drug level assay at [email protected].

  • Ixekizumab

    Ixekizumab is a humanized monoclonal antibody directed against the pro-inflammatory interleukin 17 alpha (IL17A). Ixekizumab is being used in the treatment of plaque psoriasis and psoriatic arthritis.

    Read more about Ixekizumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Mepolizumab

    Mepolizumab is a humanized monoclonal antibody directed against interleukin 5 (IL5). Mepolizumab is being used in the treatment of severe refractory (eosinophilic) asthma.

    Read more about mepolizumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Reslizumab

    Reslizumab is a humanized monoclonal antibody directed against interleukin 5 (IL5). Reslizumab is being used in the treatment of severe (eosinophilic) asthma.

    Read more about reslizumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Secukinumab

    Secukinumab is a human monoclonal antibody directed against the pro-inflammatory interleukin 17 alpha (IL17A). Secukinumab is being used in the treatment of multiple autoimmune diseases.

    Read more about secukinumab.

    Enquire about our validated drug level and ADA testing by emailing us at [email protected].

  • Tocilizumab

    Tocilizumab is a humanised IgG1 monoclonal antibody directed against the receptor of the human pro-inflammatory cytokine IL-6.

    Read more about tocilizumab.

    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

  • Ustekinumab

    Ustekinumab is a fully human IgG1κ monoclonal antibody that targets both interleukin-12 and interleukin-23.

    Read more about ustekinumab.

    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

B-cell and T-cell inhibitors | Available services

  • Abatacept

    Abatacept modulates a key costimulatory signal required for full activation of T lymphocytes expressing CD28, thereby dampening T lymphocyte-dependent antibody responses and inflammation.

    Read more about abatacept.

    To use our drug level testing services, fill out this form.

  • Alemtuzumab

    Alemtuzumab is a humanized monoclonal antibody directed against CD52. Alemtuzumab is being used in the treatment of CD52 expressing tumours and relapsing remitting form of multiple sclerosis.

    Read more about alemtuzumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Belimumab

    Belimumab is a human monoclonal antibody directed against B-lymphocyte stimulator (BLyS, also commonly known as BAFF). Belimumab is being used in the treatment of autoimmune diseases.

    Read more about belimumab.

    Enquire about our validated drug level and ADA assays at [email protected].

  • Daratumumab

    Daratumumab is a human monoclonal antibody directed against CD38. Daratumumab is being used in the treatment of CD38 expressing tumours.

    Read more about daratumumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Ocrelizumab

    Ocrelizumab is a humanized monoclonal antibody directed against CD20 present on B‑lymphocytes. Ocrelizumab is used to treat of relapsing forms of multiple sclerosis.

    Read more about ocrelizumab.

    Enquire about our validated drug level and ADA assays by emailing us at [email protected]

  • Rituximab

    Rituximab is a monoclonal antibody directed against CD20 protein present on B‑lymphocytes. Rituximab is used to treat various blood cancers and inflammatory conditions.

    Read more about rituximab.

    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

Integrin inhibitors | Available services

  • Natalizumab

    Natalizumab inhibits adhesion-molecule via binding to α4β1 integrin, and is thought to prevent migration of inflammatory cells into the brain in multiple sclerosis. 

    Read more about natalizumab.
    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

  • Vedolizumab

    Vedolizumab is a monoclonal antibody directed at α4β7 integrin, that reduces inflammation specifically in the gut.

    Read more about vedolizumab.
    To use our drug level and ADA testing services, fill out this form.

    To use our drug level and ADA testing services via remote collected finger prick, fill out this form.

PD-1/ PD-L1 inhibitors | Available services

  • Atezolizumab

    Atezolizumab is a humanized monoclonal antibody directed at human programmed death-ligand 1 (PD-L1), a negative regulator of T-cell activity. Atezolizumab potentiates T-cell responses, including anti-tumour responses.

    Read more about atezolizumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Avelumab

    Avelumab is a human monoclonal antibody directed at human programmed death-ligand 1 (PD-L1), a negative regulator of T-cell activity. Avelumab potentiates T-cell responses, including anti-tumour responses.

    Read more about avelumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Durvalumab

    Durvalumab is a human monoclonal antibody directed at human programmed death-ligand 1 (PD-L1), a negative regulator of T-cell activity. Durvalumab potentiates T-cell responses, including anti-tumour responses.

    Read more about durvalumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Nivolumab

    Nivolumab is a human monoclonal antibody directed at PD-1 receptor, a negative regulator of T-cell activity. Nivolumab potentiates T-cell responses, including anti-tumour responses.

    Read more about nivolumab.

    Enquire about our validated drug level and ADA assays by emailing us at [email protected]

  • Pembrolizumab

    Pembrolizumab is a humanized monoclonal antibody directed at programmed death-1 (PD-1) receptor, a negative regulator of T-cell activity. Pembrolizumab potentiates T-cell responses, including anti-tumour responses.

    Read more about pembrolizumab.

    Enquire about our validated drug level and ADA assays by emailing us at [email protected]

PCSK9 inhibitors | Available services

  • Alirocumab

    Alirocumab is a human monoclonal antibody directed at proprotein convertase subtilisin kexin type 9 (PCSK9) and has been shown to reduce low-density lipoprotein (LDL) cholesterol levels.

    Read more about alirocumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

  • Evolocumab

    Evolocumab is a human monoclonal antibody directed at proprotein convertase subtilisin kexin type 9 (PCSK9) and has been shown to reduce low-density lipoprotein (LDL) cholesterol levels.

    Read more about evolocumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].

Other effector mechanisms | Available services

  • Eculizumab | Complement C5 inhibitor

    Eculizumab is a humanised monoclonal antibody that targets human C5 complement protein and inhibits the activation of terminal complement. 

    Read more about eculizumab.

    To use our drug level testing services, email us at [email protected].

  • Trastuzumab | HER2 inhibitor

    Trastuzumab is a recombinant humanised IgG1 monoclonal antibody against the human epidermal growth factor receptor 2 (HER2), which is overexpressed in about 20-30% of primary breast cancers.

    Read more about trastuzumab.

    To use our drug level and ADA testing services, email us at [email protected].

  • Omalizumab | IgE inhibitor

    Omalizumab prevents binding of IgE to the high-affinity IgE receptor (FcRI), and thereby reduces the amount of free IgE that is available to trigger the allergic cascade

    Read more about omalizumab.

    To use our drug level and ADA testing services, email us at [email protected].

  • Pertuzumab I HER2 inhibitor

    Pertuzumab is a human monoclonal antibody directed against  the human epidermal growth factor receptor 2 protein (HER2), a protein found on HER2-positive cancer cells. By attaching to HER2, pertuzumab inhibits HER2 producing signals that cause the cancer cells to grow.

    Read more about pertuzumab.

    Currently in development, enquire about our fast track assay validation by emailing us at [email protected].