Antigen-specific lymphocyte analyses
Antigen-specific cells play an important role in many types of disease and are therefore important targets in immunotherapy.
In the immune-oncology field tumor-associated antigens or neo-antigens importantly affect therapy efficacy.
In vaccine development, not only antigen-specific B cells are important, but also antigen-specific T cells are more and more recognized as playing a central role.
Other fields can benefit as well from targeting antigen-specific cells, including auto-immune diseases.
Antigen-specific responses can either be investigated in total PBMC cultures or in co-cultures of monocyte-derived dendritic cells with isolated T cells. If required, these cultures can be performed with healthy donors of a specific HLA type. Furthermore, we can either repeatedly use the same donor or use several different donors. We have a selection of donors available who are responsive to specific antigens.