Our interests resides in B cells to phagocytes, from vaccination or immunization to cellular immune responses. In particular, our research emphasizes antibody biology, cloning and engineering, including research on antibody interactions with immune molecules (FcRn, FcγR, and complement). We are particularly interested in how immunoglobulins affect modulation of immune responses, particularly in the context of antibody-mediated blood cell destruction in allo- and autoimmune diseases. To this aim we have pioneered analysis and engineering of antigen specific immunoglobulin Fc-glycosylation, to understand the role of IgG-glycosylation in these and other diseases.
- Dutch Medical Research Council (ZonMW)
- LSBR (Landsteiner Foundation for Blood Transfusion Research)
- PPOP PPOD PPOC internal funding (in competition), various grants