Timon (T) Damelang PhD
Training
Infection Biology and Immunology
Research interests
Antibody diversity - the impact of IgG polymorphisms on antibody effector functions
Technology
- ELISA
- Luminex assays
- biolayer interferometry
- antibody expression and purification
- functional antibody-dependent cell-based assays
- flow cytometry
- LabChip microfluidic capillary gel electrophoresis
- PCR
- DNA sequencing
Resume
| 2021- current | Postdoctoral Researcher, Sanquin and Landsteiner Laboratory, The Netherlands Project: Antibody diversity - the impact of IgG polymorphisms on antibody effector functions |
| 2021 | Research Assistant, Doherty Institute at University of Melbourne, Australia Project: Importance of IgG3 polymorphisms in placental malaria |
| 2017-2021 | PhD in Immunology, Doherty Institute at University of Melbourne, Australia Project: Functional antibodies in pregnant women with malaria |
| 2013-2015 | MSc in Infection Biology, Research Centre Borstel and University to Lübeck, Germany Project: Investigation of MDSCs during coinfection with M. bovis BCG and P. berghei |
| 2010-2013 | BSc in Biology, Martin-Luther-University Halle-Wittenberg, Germany Project: Complementation studies of mutants of the NarX-NarL-system of S. coelicolor A3(2) |
Key publication
Hensen L, Nguyen THO, Rowntree LC, Damelang T, Koutsakos M, Aban M, Hurt A, Harland KL, Auladell M, van de Sandt CE, Everitt A, Blacker C, Oyong DA, Loughland JR, Webb JR, Wines BD, Hogarth PM, Flanagan KL, Plebanski M, Wheatley A, Chung AW, Kent SJ, Miller A, Clemens EB, Doherty PC, Nelson J, Davies J, Tong SYC, Kedzierska K. Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2109388118. Abstract
Aitken EH, Damelang T, Ortega-Pajares A, Alemu A, Hasang W, Dini S, Unger HW, Ome-Kaius M, Nielsen MA, Salanti A, Smith J, Kent S, Hogarth PM, Wines BD, Simpson JA, Chung AW, Rogerson SJ. Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria. Elife. 2021 Jun 29;10:e65776. Abstract
Damelang T, Aitken EH, Hasang W, Lopez E, Killian M, Unger HW, Salanti A, Shub A, McCarthy E, Kedzierska K, Lappas M, Kent SJ, Rogerson SJ, Chung AW. Antibody mediated activation of natural killer cells in malaria exposed pregnant women. Sci Rep. 2021 Feb 18;11(1):4130. Abstract
Fischer M, Falke D, Rönitz J, Haase A, Damelang T, Pawlik T, Sawers RG. Hypoxia-induced synthesis of respiratory nitrate reductase 2 of Streptomyces coelicolor A3(2) depends on the histidine kinase OsdK in mycelium but not in spores. Microbiology (Reading). 2019 Aug;165(8):905-916. Abstract
Damelang T, Rogerson SJ, Kent SJ, Chung AW. Role of IgG3 in Infectious Diseases. Trends Immunol. 2019 Mar;40(3):197-211. doi: 10.1016/j.it.2019.01.005. Abstract
Zelmer A, Tanner R, Stylianou E, Damelang T, Morris S, Izzo A, Williams A, Sharpe S, Pepponi I, Walker B, Hokey DA, McShane H, Brennan M, Fletcher H. A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis. BMC Infect Dis. 2016 Aug 12;16:412. doi: 10.1186/s12879-016-1751-4. Abtsract
