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Chapters

In vitro blood production from induced pluripotent stem cells

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Introduction

1.1 General introduction

1.2 Erythropoiesis and Megakaryopoiesis in a Dish

Abstract

Results

2.1 Generation of multiple iPSC lines 

Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts Abstract

Generation and characterization of human iPSC lines SANi001-A and SANi002-A from mobilized peripheral blood derived megakaryoblasts Abstract

Generation and characterization of a human iPSC line SANi005-A containing the gray platelet associated in GFI1B.heterozygous mutation p.Q287* Abstract

Generation of human erythroblast-derived iPSC line using episomal reprogramming system Abstract

2.2 Efficient production of erythroid, megakaryocytic and myeloid cells, using single cell-derived iPSC colony differentiation.

Abstract

2.3 Human induced pluripotent stem cell-derived blood products: state of the art and future directions.

Abstract

2.4 LSD1/KDM1A and GFI1B orchestrate hematopoietic emergence from induced pluripotent stem cells.


2.5 Molecular mechanisms of bleeding disorder-associated GFI1B Q287* mutation and its affected pathways in megakaryocytes and platelets.

Abstracts

2.6 The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.

Abstract

Discussion

3.1 General discussion

 

Appendix

4.1 Een decennium geïnduceerde pluripotente stamcellen; een overzicht.

Abstract

4.2 Summary/samenvatting