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Chapters

B cell and antibody differentiation: the contribution of glycans to repertoire diversification and classification

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Chapter 1

General introduction and scope of this thesis

Chapter 2

Improving naive B cell isolation by absence of CD45RB glycosylation and CD27 expression in combination with BCR isotype abstract

Chapter 3

CD45RB glycosylation and lg isotype define maturation of functionally distinct B cell subsets in human peripheral blood abstract

Chapter 4

Optimized protocols for in vitro T cell-dependent and T cell-independent activation for B cell differentiation studies using limited cells abstract

Chapter 5

Oxygen level is a critica! regulator of human B cell differentiation and IgG class switch recombination abstract

Chapter 6

Biased N-glycosylation site distribution and acquisition across the antibody V region during B cell maturation abstract

Chapter 7

Differences in IgG autoantibody Fab glycosylation across autoimmune diseases abstract

Chapter 8

Elevated Fab glycosylation of anti-hinge antibodies abstract

Chapter 9

Summarizing Discussion