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Chapters

B Cells and Beyond: Regulation of human B cell differentiation and antibody formation.

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Chapter 1 

General introduction and scope of this thesis 

Chapter 2

Human B Cells engage the NCK/PI3K/RACl axis to internalize large particles via the IgM-BCR Abstract

Chapter 3

Elucidation of in vitro requirements for efficient human naive B cell differentiation into antibody-secreting cells 

Chapter 4

Elucidation of human naive B cell to antibody-secreting cell differentiation trajectories using single-cell transcriptome analyses 

Chapter 5

Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses Abstract

Chapter 6

Repeated vaccination with tetanus toxoid of plasma donors with pre-existing specific IgE transiently elevates tetanus-specific IgE but does not induce allergic symptoms Abstract

Chapter 7

In vitro-induced human IL-l0+ B cells do not show a subset-defining marker signature and plastically co-express IL-l0 with pro-inflammatory cytokines Abstract

Chapter 8

Summarizing Discussion