To bind or not to bind: A study into FcRn interactions

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Chapter 1 

General introduction

Chapter 2

Short half-life of human IgG3 due to competition for FcRn-mediated transport reveals its therapeutic potential

Chapter 3

On the perplexingly low rate of transport of IgG2 across the human placenta Abstract

Chapter 4 

Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport Abstract

Chapter 5

Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge Abstract

Chapter 6

FcRn: an IgG Receptor on Phagocytes with a Novel Role in Phagocytosis Abstract

Chapter 7

General discussion