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Chapters

‘Le charme discret’ of the Von Willebrand factor - factor VIII complex

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Chapter 1

Introduction

Chapter 2

D’ domain region Arg782-Cys799 of Von Willebrand Factor contributes to Factor VIII binding Abstract

Chapter 3

The D’ domain of von Willebrand factor requires the presence of the D3 domain for optimal factor VIII binding Abstract

Chapter 4

Endocytosis by macrophages: Interplay of macrophage scavenger receptor-1 and LDL receptor-related protein-1 Abstract

Chapter 5

Unique solvent-exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and Von Willebrand Factor binding Abstract

Chapter 6

General discussion