Tuning the Show: Genetic engineering to unravel antigen presentation by the Human Leukocyte Antigen class I

Download thesis (university repository, when available)

Chapter 1

General introduction and scope of this thesis

Chapter 2

PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin Abstract

Chapter 3

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens Abstract

Chapter 4

HLA-I allelic dependencies on components of the peptide-loading complex

Chapter 5

The role of glycosphingolipids in immune cell functions Abstract

Chapter 6

The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses Abstract

Chapter 7

Summarizing discussion