A suit of armor around ADAMTS13; Exploring paths towards resistance against autoantibodies of immune TTP patients

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Chapter 1

The “Nautical Chart” of Thrombotic Thrombocytopenic Purpura – a General Introduction

Chapter 2

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers Abstract

Chapter 3

Immunogenic hotspots in the spacer domain of ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura Abstract

Chapter 4

Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura Abstract

Chapter 5

N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP Abstract

Chapter 6

Modelling-assisted identification of CUB1/2 domain residues involved in maintaining ADAMTS13 in a closed conformation

Chapter 7

General Discussion