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Chapters

Dynamics of TNF during TNF inhibitor treatment

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Chapter 1

General introduction

Chapter 2

Dynamics of circulating TNF during adalimumab treatment using a drug-tolerant TNF assay abstract

Chapter 3

The effect of methotrexate on tumor necrosis factor concentrations in etanercept-treated rheumatoid arthritis patients abstract

Chapter 4

Comment on ‘Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomized controlled trial’ by Tanaka et al. abstract

Chapter 5

Formation and clearance of TNF-TNF inhibitor complexes during TNF inhibitor treatment

Chapter 6

The effect of certolizumab drug concentration and anti-drug antibodies on TNF neutralization abstract

Chapter 7

Summarizing discussion