A sweet touch on ADAMTS13: Insights into the pathophysiology of immune TTP

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Chapter 1

General introduction

Chapter 2

Insights into 3D-structure of ADAMTS13: a stepping stone towards novel therapeutic treatment of TTP Abstract

Chapter 3

Child‐onset thrombotic thrombocytopenic purpura caused by p. R498C and p. G259PfsX133 mutations in ADAMTS13 Abstract

Chapter 4

Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura Abstract

Chapter 5

N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP Abstract

Chapter 6

Modelling-assisted identification of CUB1/2 domain residues involved in maintaining ADAMTS13 in a closed conformation

Chapter 7

Conformational plasticity of ADAMTS13 in immune TTP;a blood-based remake of Dr. Jekyll and Mr. Hyde

Chapter 8

Rational modulator design by exploitation of protein-protein complex structures Abstract

Chapter 9

Structure-based design of cyclic glycoprotein Ibα-derived peptides affecting platelet interaction with von Willebrand factor under shear conditions

Chapter 10

General discussion