Chapters
A sweet touch on ADAMTS13: Insights into the pathophysiology of immune TTPDownload thesis (from university repository, when available)
Chapter 1
General introduction
Chapter 2
Insights into 3D-structure of ADAMTS13: a stepping stone towards novel therapeutic treatment of TTP Abstract
Chapter 3
Child‐onset thrombotic thrombocytopenic purpura caused by p. R498C and p. G259PfsX133 mutations in ADAMTS13 Abstract
Chapter 4
Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura Abstract
Chapter 5
N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP Abstract
Chapter 6
Modelling-assisted identification of CUB1/2 domain residues involved in maintaining ADAMTS13 in a closed conformation
Chapter 7
Conformational plasticity of ADAMTS13 in immune TTP;a blood-based remake of Dr. Jekyll and Mr. Hyde
Chapter 8
Rational modulator design by exploitation of protein-protein complex structures Abstract
Chapter 9
Structure-based design of cyclic glycoprotein Ibα-derived peptides affecting platelet interaction with von Willebrand factor under shear conditions
Chapter 10
General discussion
