Regulation of complement activation on red blood cells

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Chapter 1

Introduction and scope of this thesis

Chapter 2

Consequences of dysregulated complement regulators on red blood cells Abstract

Chapter 3

Complement regulator CD46 expression is lost gradually during erythropoiesis and enucleation

Chapter 4

Complement deposition and IgG binding on stored red blood cells are independent of storage time

Chapter 5

Blocking the binding region domains 6-8 of factor H inhibits its complement regulation function on human red blood cells

Chapter 6

CRISPR/Cas9 generated human CD46, CD55 and CD59 knockout cell lines as a tool for complement research Abstract

Chapter 7

The amplification loop is not required for efficient classical complement pathway activation

Chapter 8

Summarizing discussion