header-image

Stem cell biology

Key publications

Walasek MA, van Os R, de Haan G Hematopoietic stem cell expansion: challenges and opportunities. Ann N Y Acad Sci. (2012) Aug;1266:138-50

Karin Klauke, Visnja Radulovic, Mathilde J.C. Broekhuis, Ellen Weersing, Erik Zwart, Sandra Olthof, Martha Ritsema, Sophia Bruggeman, Xudong Wu*, Kristian Helin*, Leonid Bystrykh, and Gerald de Haan (2013).  Polycomb Cbx orthologs mediate the balance between Hematopoietic Stem Cell self-renewal and differentiation. Nat Cell Biol. 2013 Apr;15(4):353-62.

Verovskaya E, Broekhuis MJ, Zwart E, Ritsema M, van Os R, de Haan G, Bystrykh LV (2013). Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding. Blood 122 (4): 523-32.

Evgenia Verovskaya, Mathilde J.C. Broekhuis, Erik Zwart, Ellen Weersing, Martha Ritsema, Lisette Bosman, Theo van Poele, Gerald de Haan#, Leonid V. Bystrykh# (2014). Asymmetry in skeletal distribution of murine hematopoietic stem cell clones and their equilibration by mobilizing cytokines. J. Exp.Med, 2014 Mar 10;211(3):487-97.

Edyta E. Wojtowicz, Eric R. Lechman, Karin G. Hermans, Erwin M. Schoof, Erno Wienholds, Ruth Isserlin, Peter A. van Veelen, Mathilde J.C. Broekhuis, George. M.C. Janssen, Aaron Trotman-Grant, Stephanie M. Dobson2, Gabriella Krivdova, Jantje Elzinga, James Kennedy, Olga Gan, Ankit Sinha, Vladimir Ignatchenko, Thomas Kislinger, Ellen Weersing, Mir Farshid Alemdehy, Hans W.J. de Looper, Bader, GD, Martha Ritsema, Stefan J. Erkeland, Leonid V. Bystrykh, John E. Dick and Gerald de Haan. Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors. Cell Stem Cell. 2016 Sep 1;19(3):383-96. doi: 10.1016/j.stem.2016.06.008.

Mirjam E. Belderbos, Taco Koster, Bertien Dethmers-Ausema, Sabrina Jacobs, Sharlaine Sowdagar, Erik Zwart, Eveline de Bont, Gerald de Haan, Leonid V. Bystrykh.  Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding. Blood. 2017 Jun 15;129(24):3210-20. PMID: 28396495

Yang Han, Monika Eipel, Julia Franzen, Vadim Sakk, Bertien Dethmers-Ausema, Laura Yndriago, Ander Izeta, Gerald de Haan, Hartmut Geiger and Wolfgang Wagner. Epigenetic Age-Predictor for Mice based on Three CpG Sites. Elife. 2018 Aug 24;7. pii: e37462. doi: 10.7554/eLife.37462

Jung J, Buisman SC, Weersing E , Dethmers-Ausema B1, Zwart E, Schepers H, Dekker MR, Lazare SS, Hammerl F, Skokova J, Kooistra SM, Klauke K, Poot RA, Bystrykh LV and de Haan G. CBX7 induces self-renewal of human normal and malignant hematopoietic stem and progenitor cells by canonical and non-canonical interactions. Cell Rep. 2019 Feb 12;26(7):1906-18

Jacobs S, Ausema A, Zwart E, Weersing E, Kingma MJ, El Menshawi YAS, de Haan G, Bystrykh LV, Belderbos ME. Quantitative distribution of patient-derived leukemia clones in murine xenografts revealed by cellular barcodes. Leukemia. Epub 2019 Dec 18.

Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Seka Lazare , Bertien Dethmers-Ausema, Erik Zwart, Anna Rita Redavid, Benjamin Gibert, Manon Tourbez, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp. Niche Derived Netrin-1 Regulates Hematopoietic Stem Cell Dormancy via its Receptor Neogenin-1. Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. Nat Commun 12, 608 (2021). https://doi.org/10.1038/s41467-020-20801-0.

Svendsen AF, Yang D, Kim KM, Lazare S, Skinder N, Zwart E, Mura-Meszaros A, Ausema A, von Eyss B, de Haan G*, Bystrykh LV*. A comprehensive transcriptome signature of murine hematopoietic stem cell aging. Blood. 2021 Apr 19;blood.2020009729. doi: 10.1182/blood.2020009729