Maartje (M.) van den Biggelaar PhD
Training
Pharmaceutical Sciences, Utrecht University
Thesis
'Factor VIII trafficking to Weibel-Palade bodies'
2008 - Utrecht University
Research interests
The aim of my research is to develop innovative protein therapeutics for hemostatic disorders and my long lasting interest is in the biology of hemostatic proteins, with particular emphasis on von Willebrand factor and Factor VIII. The goals are (1) to understand the interaction of hemostatic proteins with endocytic receptors and (2) to identify communication networks between the hemostatic system and the vasculature. Unravelling these interactions and signaling networks is essential to develop rational approaches for the design of improved therapeutic coagulation proteins and to reveal novel targets for therapeutic intervention in hemostatic disorders.
Technology
- Confocal laser scanning microscopy
- Surface Plasmon Resonance analysis using Biacore
- Recombinant protein production and immunoaffinity purification
- Mass spectrometry-based quantitative phosphoproteomics
Resume
| 2013-present | Scientist at the Dept of Plasma Proteins, Sanquin Research, Amsterdam |
| 2011-2013 | Visiting scientist, The Beatson Institute for Cancer Research,Glasgow, UK (S Zanivan PhD) |
| 2007-2012 | Postdoctoral Scientist at the Dept of Plasma Proteins, Sanquin Research, Amsterdam |
| 2005 | Laboratory of Genetics, SALK Institute, La Jolla, CA, USA (Prof Inder Verma PhD) |
| 2002-2007 | PhD student, Utrecht University |
| 2013 | XXIVth International Society of Thrombosis and Haemostasis Congress, Amsterdam, the Netherlands. Young Investigator Award |
| 2009 | XXIIth International Society of Thrombosis and Haemostasis Congress, Boston, USA. Young Investigator Award |
| 2008 | Gordon Research Conference, Proprotein processing, trafficking & secretion, New London, New Hampshire, USA NIH grant |
| 2007 | 49th American Society of Hematology Annual Meeting, Atlanta, Georgia, USA ASH travel award |
| 2005 | XXth International Society of Thrombosis and Haemostasis Congress, Sydney, Australia Young investigator award |
| 2005 | XXth International Society of Thrombosis and Haemostasis Congress, Sydney, Australia. NVTH-ISTH travel award |
