header-image

Rick (K) Kapur MD PhD

Training

Biology/Biomedical Sciences (BSc, MSc), Medicine (MD), Immunohematology (PhD)

Thesis

Multifactorial aspects of antibody‐mediated blood cell destruction
University of Amsterdam, Amsterdam, March 18, 2014 

Research interests

Dissection of pathophysiological mechanisms in Transfusion Medicine, with focus on Transfusion-related acute lung injury (TRALI), antibody-mediated hematological disorders including immune thrombocytopenia (ITP), fetal and neonatal alloimmune thrombocytopenia (FNAIT), hemolytic disease of the fetus and newborn (HDFN). Additional interests include immune functions of platelets.

Technologies: experimental mouse models, diverse immunological assays including phagocytosis and respiratory burst assays.

Resume

2019 - present

Researcher at Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

2017 - 2019

Post-doctoral fellow at Lund University, Lund, Sweden.

2015 - 2017

Post-doctoral fellow at Canadian Blood Services, Toronto Platelet Immunobiology Group, Keenan Research Center for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

2009-2014

PhD at Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Thesis: “Multifactorial Aspects of Antibody-Mediated Blood Cell Destruction”. Supervisor: Prof. Dr. C.E. van der Schoot. Co-supervisor: Dr. G. Vidarsson.

2004-2008

MD at SUMMA (Selective Utrecht Medical Masters), University Medical Center Utrecht, Utrecht University, The Netherlands.

1998-2004

BSc and MSc in Biology with specialization in Fundamental Biomedical Sciences, Faculty of Biology, Utrecht University, The Netherlands.

 

Other publications

Rebetz J, Semple JW and KAPUR R. The pathogenic involvement of neutrophils in Acute Respiratory Distress Syndrome (ARDS) and Transfusion-related acute lung injury (TRALI). Transfus Med Hemother 2018; 45(5):290-298.

Semple JW, Rebetz J and KAPUR R. Transfusion-associated circulatory overload (TACO): Time to shed light on the pathophysiology. ISBT Science Series 2018; in press. 

Semple JW and KAPUR R.  Moving target PF4 directs HIT responses. Blood 2018; 132(7):678-679. Editorial.

KAPUR R, Kim M, Rebetz J, Hallström B, Björkman JT, Takabe-French A, Kim N, Liu J, Shanmugabhavananthan S, Milosevic S, McVey MJ, Speck ER, Semple JW.  Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury. Blood Advances 2018; 2(13):1651-1663.

Guo L*, KAPUR R*, Aslam R, Hunt K, Hou Y, Zufferey A, Speck ER, Rondina MT, Lazarus AH, Ni H, Semple JW. Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia. Scandinavian Journal of Immunology 2018; 88(1):e12678. * Equally contributed.

Semple JW, McVey MJ, Kim M, Rebetz J, Kuebler WM and KAPUR R.  Targeting Transfusion-Related Acute Lung Injury: The Journey from Basic Science to Novel Therapies. Critical Care Medicine 2018; 46(5):e452-e458.

KAPUR R, Semple JW. Platelet Immunobiology: platelets as prey and predator. ISBT Science Series 2018;13:87-92. 

KAPUR R*, Catalina MD*, Aslam R, Speck ER, Francovitch R, Semple JW. A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP). Br J Haematol 2018; 183(3):501-503. * Equally contributed.

Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, KAPUR R, Boilard E, Italiano Jr, JE, Semple JW. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Advances 2017;1:1773-1785.

KAPUR R, Kim M, Rebetz J, Rondina MT, Porcelijn L, Semple JW. Low Levels of Interleukin-10 in Patients with Transfusion-Related Acute Lung Injury. Ann Transl Med  2017;5(16):339. 

Zufferey A, KAPUR R, Semple JW. Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). J Clin Med 2017;6(2).

KAPUR R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER, Zufferey A, Yousef G, Zhang H, Rondina MT, Weyrich AS, Porcelijn L, Kuebler WM, Slutsky AS, Semple JW.T Regulatory Cells and Dendritic Cells Protect Against Transfusion-Related Acute Lung Injury via IL-10. Blood. 2017; 129(18): 2557-69.

KAPUR R, Aslam A, Kim A, Guo L, Ni H, Segel GB, Semple JW. Thymic-derived tolerizing dendritic cells are up-regulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia. Platelets 2017; 28(5):521-524.     

KAPUR R, Semple JW. Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2. Ann Transl Med 2016;4(24):488. Editorial.

KAPUR R, Semple JW. Platelets as immune-sensing cells. Blood Advances 2016;1(1):10-14.                                                                                                                                  
KAPUR R, Kim M, Rondina MT, Porcelijn L, Semple JW. Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury. Oncotarget. 2016;7(47):78048-78054.      

Aslam R*, KAPUR R*, Segel GB, Guo L, Zufferey A, Ni H, Semple JW. The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia. Exp Hematol. 2016;44(10):924-930. * Equally contributed.

KAPUR R, Semple JW. The nonhemostatic immune functions of platelets. Semin Hematol. 2016; 53 Suppl 1:S2-6.   

Guo L, KAPUR R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW. CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia. Blood. 2016;11;127(6):735-8.

KAPUR R, Kim M, Shanmugabhavananthan S, Liu J, Li Y, Semple JW. C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury (TRALI). Blood. 2015;126(25):2747-51.

KAPUR R, Zufferey A, Boilard E, Semple JW. Nouvelle cuisine: platelets served with inflammation. J Immunol. 2015;194(12):5579-87.

KAPUR R, Stramrood CA, Schutgens RE, van Asbeck BS. Cyproterone acetate- and ethinyloestradiol-containing oral contraceptive as a risk factor for upper extremity deep venous thrombosis-a case report. Eur J Contracept Reprod Health Care. 2009;14(2):160-3

KAPUR R, Ebeling S, Hagenbeek A. B-cell involvement in chronic graft-versus-host disease. Haematologica. 2008;93(11):1702-11

Chandra S, Levran O, Jurickova I, Maas C, KAPUR R, Schindler D, Henry R, Milton K, Batish SD, Cancelas JA, Hanenberg H, Auerbach AD, Williams DA. A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Mol Ther. 2005;12(5):976-84

Verwaal R, Arako M, KAPUR R, Verkleij AJ, Verrips CT, Boonstra J. HXT5 expression is under control of STRE and HAP elements in the HXT5 promoter. Yeast. 2004;21(9):747-57.