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Marieke (M. M.) von Lindern PhD

Training

Molecular Biology

Thesis

'Molecular Characterization of translocation (6;9) in Acute Nonlymphocytic Leukemia'
Promotor: Prof. D. Bootsma
Co-promotor: Dr G. Grosveld
June 1992 - Erasmus University Rotterdam

Research interests

Expansion and differentiation of erythroblasts. We developed an in vitro cell system in which erythroid progenitors can be expanded in presence of Epo, SCF and glucocorticoids, while retaining the capacity to undergo complete and synchronous differentiation to mature erythrocytes. In this model system we study how SCF inhibits differentiation and sustains proliferation of erythroblasts. Since we discovered an important role for selective mRNA translation in erythropoiesis, the mechanism of selective mRNA translation, the role of deregulated translation in anemia, and the cellular processes controlled at the level of selective mRNA translation are at the centre of our investigations.

Technology

  • Standard techniques in molecular biology and biochemistry
  • Isolation and analysis of polyribosomes to assay translation initiation
  • Ribosome profiling
  • In vitro culture of primary erythroid cells derived from mouse fetal liver, bone marrow or ES-cells, or from human peripheral blood or bone marrow

Resume

2012-present Associate professor (UHD) at the Dept Hematology, AMC, UvA, Amsterdam
2010-present Head of the Dept Hematopoiesis, Sanquin Research and Landsteiner Laboratory
2010-present Associate professor (UHD) at the Dept Hematology, ErasmusMC, Rotterdam (as guest)
2006-2010 Associate professor (UHD) at the Dept Hematology, ErasmusMC, Rotterdam. Full position
1996-2006 Senior scientist at the Dept Hematology, ErasmusMC, Rotterdam
1992-1995 Postdoc at the Institute of Molecular Pathology , Vienna, Austria. Studying erythropoiesis with dr. Hartmut Beug
1986-1992 PhD studies at the Dept Cell Biology and Genetics, Erasmus University Rotterdam
1986 Graduated in Biology, University of Leiden

Other academic activities

2010-present Member of the Leukemia and Lymphoma Research (LLR, London, UK) research committee

Other activities

Chair of the Beug Foundation for Metastasis Research.
The Beug Foundation for Metastasis Research supports basic research on the mechanisms that underlie cancer metastasis, and promotes the cooperation between basic and pharmaceutical research to develop novel therapies.