Influence of immunoglobulin G-glycan and subclass variation on antibody effector functions

Chapter 1

General introduction and scope of the thesis

Chapter 2

Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans. abstract

Chapter 3

Decoding the human IgG-glycan repertoire reveals a spectrum of Fc-receptor- and complementmediated-effector activities

Chapter 4

Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages. abstract

Chapter 5

Enhanced effector functions due to antibody defucosylation depend on the effector cell Fcγ receptor profile. abstract

Chapter 6

Affinity of human IgG subclasses to mouse Fc gamma receptors. abstract

Chapter 7

Conserved FcγR- glycan discriminates between fucosylated and afucosylated IgG in humans and mice

Chapter 8

Hinge-region O-glycosylation of human immunoglobulin G3 (IgG3). abstract

Chapter 9

General discussion