Chapters
Chapter 1
General introduction and scope of this thesis
Chapter 2
Histones, cell-free DNA, or nucleosomes: the immunity of extracellular chromatin unraveled.
Chapter 3
Cooperation of Factor VII-activating protease and serum Deoxyribonuclease I in release of nucleosomes from necrotic cells.
Arthritis Rheumatol 2014; 66(3):686-93.
Chapter 4
FSAP-mediated nucleosome release from late apoptotic cells is inhibited by autoantibodies present in SLE.
Eur J Immunol 2016; 46(3):762-71.
Chapter 5
DNA and Factor VII-activating protease protect against the cytotoxicity of histones.
Chapter 6
Factor VII-activating protease mediates the degradation of HMGB1.
Chapter 7
Cellular RNA and histones play synergistic but distinct roles in FSAP activation induced by dead cells in serum.
Chapter 8
Summarizing discussion
