Hanke (H. L.) Matlung PhD


Biomedical Engineering


'Inflammation and transglutaminases in vascular remodeling and atherosclerosis, at the department of Biomedical Engineering and Physics'
2011 - University of Amsterdam

Research interests

To study interactions between CD47 and Signal Regulatory Protein alpha (SIRPa) in antibody dependent cellular cytotoxicity of neutrophils against tumor cells.


  • In vivo: mouse models
  • In vitro: cell culture (primary, cell lines) and isolated (murine) vessel culture
  • Immunohistochemistry
  • RT-PCR


2011-present Postdoctoral fellow at the Dept of Blood Cell Research, Sanquin Research, Amsterdam
2006-2010 PhD student at the department of Biomedical Engineering and Physics, AMC Amsterdam, the Netherlands
2004-2004 Traineeship at the National University of Singapore (NUS), faculty Biomedical Engineering
1999-2006 Biomedical Engineering, University of Technology Eindhoven, the Netherlands

Other publications

Van den Akker J, VanBavel E, van Geel R, Matlung HL, Janssen GMC, van Veelen PA, Boelens WC, De Mey JGR, Bakker EN. The redox state of transglutaminase 2 controls arterial remodeling. PlosOne, 2011; 6(8):e23067. Epub 2011 Aug 25.

Matlung HL, VanBavel E, van den Akker J, de Vries CJ, Bakker EN. Role of transglutaminases in cuff‐induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice. Atherosclerosis 2010; 213(1):77-84.

Bonta PI, Matlung HL, Vos M, Peters SL, Pannekoek H, Bakker EN, de Vries CJ. Nuclear Receptor Nur77 inhibits vascular outward remodeling and reduces macrophage accumulation and matrix metalloproteinase levels. Cardiovasc Res. 2010; 87(3):561-8.

Taherzadeh Z, VanBavel E, de Vos J, Matlung HL, van Montfrans GA, Brewster LM, Seghers L, Quax PH, Bakker EN. Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex. Am J Physiol Heart Circ Physiol. 2010; 298(4):H1273-82.

Matlung HL, Groen HC, de Vos J, van Walsum T, van der Lugt A, Niessen WJ, Wentzel JJ, VanBavel E, Bakker EN. Calcification locates to transglutaminases in advanced human atherosclerotic lesions. Am J Pathol. 2009; 175(4):1374-9.

Matlung HL, Bakker EN, VanBavel E. Shear stress, reactive oxygen species, and arterialstructure and function. Antioxid Redox Signal. 2009; 11(7):1699-709. Review.

Bakker EN, Matlung HL, Bonta P, de Vries CJ, van Rooijen N, VanBavel E. Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone. Cardiovasc Res.2008; 78(2):341-8.