Publications

• Neutrophil specific granule and NETosis defects in gray platelet syndrome.

  Aarts C E M, Downes K, Hoogendijk A J, Sprenkeler E G G, Gazendam R P, Favier R, Favier M, Tool A T J, van Hamme J L, Kostadima M A, Waller K, Zieger B, van Bergen M G J M, Langemeijer S M C, van der Reijden B A, Janssen H, van den Berg T K, van Bruggen R, Meijer A B, Ouwehand W H and Kuijpers T W. Blood Adv 2021; 5 (2): 549-564. abstract
• The Gardos effect drives erythrocyte senescence and leads to Lu/BCAM and CD44 adhesion molecule activation.

  Klei T R L, Dalimot J J, Beuger B M, Veldthuis M, Ichou F A, Verkuijlen P J J H, Seignette I M, Ligthart P C, Kuijpers T W, van Zwieten R and van Bruggen R. Blood Adv 2020; 4 (24): 6218-6229. abstract
• Loss-of-function mutations in CSF3R cause moderate neutropenia with fully mature neutrophils: two novel pedigrees.

  Sprenkeler E G G, Tool A T J, Kreft I C, van Alphen F P J, Seneviratne S L, Maimaris J, Luqmani A, van Leeuwen K, van Bruggen R, Burns S O, Kuijpers T W and Nbr-Rd Pid Consortium Nihr BioResource. Br J Haematol 2020; epub ahead of print Sep 23, 2020. abstract
• Hemolysis in the spleen drives erythrocyte turnover.

  Klei T R L, Dalimot J J, Nota B, Veldthuis M, Mul E, Rademakers T, Hoogenboezem M, Nagelkerke S Q, van IJcken W F J, Oole E, Svendsen P, Moestrup S K, van Alphen F, Meijer A B, Kuijpers T W, Zwieten R V and van Bruggen R. Blood 2020; 136 (14): 1579-1589. abstract
• Severity of illness influences the microcirculatory response to red blood cell transfusion in the critically ill: an observational cohort study.

  van Manen L, Deurvorst J M, van Hezel M E, Boshuizen M, van Bruggen R and Juffermans N P. Crit Care 2020; 24 (1): 498. abstract
• Oxidative stress activates red cell adhesion to laminin in sickle cell disease.

  Lizarralde-Iragorri M A, Lefevre S D, Cochet S, El Hoss S, Brousse V, Filipe A, Dussiot M, Azouzi S, Le Van Kim C, Rodrigues-Lima F, Francais O, Le Pioufle B, Klei T, van Bruggen R and El Nemer W. Haematologica 2020; epub ahead of print Aug 27, 2020. abstract
• Biomarkers for the Discrimination of Acute Kawasaki Disease From Infections in Childhood.

  Zandstra J, van de Geer A, Tanck M W T, van Stijn-Bringas Dimitriades D, Aarts C E M, Dietz S M, van Bruggen R, Schweintzger N A, Zenz W, Emonts M, Zavadska D, Pokorn M, Usuf E, Moll H A, Schlapbach L J, Carrol E D, Paulus S, Tsolia M, Fink C, Yeung S, Shimizu C, Tremoulet A, Galassini R, Wright V J, Martinon-Torres F, Herberg J, Burns J, Levin M, Kuijpers T W, Euclids Consortium Perform Consortium and Network U K Kawasaki Disease Genetics Study. Front Pediatr 2020; 8 355. abstract
• Treatment-associated hemolysis in Kawasaki disease: association with blood-group antibody titers in IVIG products.

  Bruggeman C W, Nagelkerke S Q, Lau W, Manlhiot C, de Haas M, van Bruggen R, McCrindle B W, Yeung R S M and Kuijpers T W. Blood Adv 2020; 4 (14): 3416-3426. abstract
• Different MDSC Activity of G-CSF/Dexamethasone Mobilized Neutrophils: Benefits to the Patient?.

  Aarts C E M, Hiemstra I H, Furumaya C, van Bruggen R and Kuijpers T W. Front Oncol 2020; 10 1110. abstract
• The association and functional relevance of genetic variation in low-to-medium-affinity Fc-gamma receptors with clinical platelet transfusion refractoriness.

  Nagelkerke S Q, Porcelijn L, Geissler J, Tanck M W T, Huiskes E, van Bruggen R, van den Berg T K, de Haas M and Kuijpers T W. J Thromb Haemost 2020; 18 (8): 2047-2053. abstract
• Colloid osmotic pressure of contemporary and novel transfusion products.

  Klanderman R B, Bosboom J J, Korsten H, Zeiler T, Musson R E A, Veelo D P, Geerts B F, van Bruggen R, de Korte D and Vlaar A P J. Vox Sang 2020; epub ahead of print May 6, 2020. abstract
• Y-RNA subtype ratios in plasma extracellular vesicles are cell type- specific and are candidate biomarkers for inflammatory diseases.

  Driedonks T A P, Mol S, de Bruin S, Peters A L, Zhang X, Lindenbergh M F S, Beuger B M, van Stalborch A D, Spaan T, de Jong E C, van der Vries E, Margadant C, van Bruggen R, Vlaar A P J, Groot Kormelink T and Nolte-'t Hoen E N M. J Extracell Vesicles 2020; 9 (1): 1764213. abstract
• Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses.

  Unger P A, Lighaam L C, Vermeulen E, Kruithof S, Makuch M, Culver E L, van Bruggen R, Remmerswaal E B M, Ten Berge I J M, Emmens R W, Niessen H W M, Barnes E, Wolbink G J, van Ham S M and Rispens T. Eur J Immunol 2020; 50 (8): 1113-1125. abstract
• MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization.

  Sprenkeler E G G, Henriet S, Tool A, Kreft I C, van der Bijl I, Aarts C C E M, van Houdt M, Verkuijlen P, van Aerde K, Jaspers G, van Heijst A, Koole W, Gardeitchik T, Geissler J, de Boer M, Tol S, Bruggeman C W, van Alphen F, Verhagen H J, van den Akker E, Janssen H, van Bruggen R, van den Berg T K, Liem K D and Kuijpers T W. Blood 2020; 135 (24): 2171-2181. abstract
• The effect of washing of stored red blood cell transfusion units on post transfusion recovery and outcome in a pneumosepsis animal model.

  van Manen L, Maas A, Roelofs J J T H, Vlaar A P J, van Bruggen R and Juffermans N P. Shock 2020; 54 (6): 794-801. abstract
• Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill.

  Boshuizen M, Binnekade J M, Nota B, van de Groep K, Cremer O L, Horn J, Schultz M J, van Bruggen R and Juffermans N P. Transfus Med Hemother 2020; 47 (1): 61-67. abstract
• Red blood cell transfusion results in adhesion of neutrophils in human endotoxemia and in critically ill patients with sepsis.

  van Hezel M E, Boshuizen M, Peters A L, Straat M, Vlaar A P, Spoelstra-de Man A M E, Tanck M W T, Tool A T J, Beuger B M, Kuijpers T W, Juffermans N P and van Bruggen R. Transfusion 2020; 60 (2): 294-302. abstract
• Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model.

  Klanderman R B, Bosboom J J, Maas A A W, Roelofs Jjth, de Korte D, van Bruggen R, van Buul J D, Zuurbier C J, Veelo D P, Hollmann M W, Vroom M B, Juffermans N P, Geerts B F and Vlaar A P J. Transfusion 2019; 59 (12): 3617-3627. abstract
• The effect of red blood cell transfusion on platelet function in critically ill patients.

  van Hezel M E, van Manen L, Boshuizen M, Straat M, De Cuyper I M, Beuger B, Nieuwland R, Tanck M W T, de Korte D, Zwaginga J J, van Bruggen R and Juffermans N P. Thromb Res 2019; 184 115-121. abstract
• Neutrophils as Suppressors of T Cell Proliferation: Does Age Matter?.

  Aarts C E M, Hiemstra I H, Tool A T J, van den Berg T K, Mul E, van Bruggen R and Kuijpers T W. Front Immunol 2019; 10 2144. abstract
• Tissue-specific expression of IgG receptors by human macrophages ex vivo.

  Bruggeman C W, Houtzager J, Dierdorp B, Kers J, Pals S T, Lutter R, van Gulik T, den Haan J M M, van den Berg T K, van Bruggen R and Kuijpers T W. PLoS One 2019; 14 (10): e0223264. abstract
• Transfusion practice in the non-bleeding critically ill: an international online survey-the TRACE survey.

  de Bruin S, Scheeren T W L, Bakker J, van Bruggen R, Vlaar A P J, Cardiovascular Dynamics Section and Transfusion Guideline Task Force of the Esicm. Crit Care 2019; 23 (1): 309. abstract
• International point prevalence study of Intensive Care Unit transfusion practices-Pilot study in the Netherlands.

  de Bruin S, Alders M Y, van Bruggen R, de Korte D, Scheeren T W L, Bakker J, Aubron C, Feldheiser A, Meier J, Cecconi M, Vlaar A P J, Cardiovascular Dynamics Section, Transfusion Task Force of the Esicm and Collaborators. Transfus Clin Biol 2019; 26 (4): 202-208. abstract
• Biotinylation of platelets for transfusion purposes a novel method to label platelets in a closed system.

  de Bruin S, van de Weerdt E K, Sijbrands D, Vlaar R, Gouwerok E, Biemond B J, Vlaar A P J, van Bruggen R and de Korte D. Transfusion 2019; 59 (9): 2964-2973. abstract
• Development of a model for anemia of inflammation that is relevant to critical care.

  Boshuizen M, van Bruggen R, Zaat S A, Schultz M J, Aguilera E, Motos A, Senussi T, Idone F A, Pelosi P, Torres A, Bassi G L and Juffermans N P. Intensive Care Med Exp 2019; 7 (Suppl 1): 47. abstract
• Identification of genetic biomarkers for alloimmunization in sickle cell disease.

  Meinderts S M, Gerritsma J J, Sins J W R, de Boer M, van Leeuwen K, Biemond B J, Rijneveld A W, Kerkhoffs J H, Habibi A, van Bruggen R, Kuijpers T W, van der Schoot E, Pirenne F, Fijnvandraat K, Tanck M W and van den Berg T K. Br J Haematol 2019; 186 (6): 887-899. abstract
• A Homozygous Mutation on the HBA1 Gene Coding for Hb Charlieu (HBA1: c.320T>C) Together with beta-Thalassemia Trait Results in Severe Hemolytic Anemia.

  Klei T R L, Kheradmand Kia S, Veldthuis M, Dehbozorgian J, Karimi M, Geissler J, Sellink E, Thiel-Valkhof M, Burger P, van Alphen F, Meijer A B, van Bruggen R and van Zwieten R. Hemoglobin 2019; 43 (2): 77-82. abstract
• Neutrophils acquire antigen-presenting cell features after phagocytosis of IgG-opsonized erythrocytes.

  Meinderts S M, Baker G, van Wijk S, Beuger B M, Geissler J, Jansen M H, Saris A, Ten Brinke A, Kuijpers T W, van den Berg T K and van Bruggen R. Blood Adv 2019; 3 (11): 1761-1773. abstract
• Clearance and phenotype of extracellular vesicles after red blood cell transfusion in a human endotoxemia model.

  van Manen L, Peters A L, van der Sluijs P M, Nieuwland R, van Bruggen R and Juffermans N P. Transfus Apher Sci 2019; 58 (4): 508-511. abstract
• Regulatory T cell features in Chronic Granulomatous Disease.

  van de Geer A, Cuadrado E, Slot M C, van Bruggen R, Amsen D and Kuijpers T W. Clin Exp Immunol 2019; 197 (2): 222-229. abstract
• FcgammaRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils.

  Treffers L W, van Houdt M, Bruggeman C W, Heineke M H, Zhao X W, van der Heijden J, Nagelkerke S Q, Verkuijlen Pjjh, Geissler J, Lissenberg-Thunnissen S, Valerius T, Peipp M, Franke K, van Bruggen R, Kuijpers T W, van Egmond M, Vidarsson G, Matlung H L and van den Berg T K. Front Immunol 2019; 9 (30 jan): 3124. abstract
• The effect of red blood cell transfusion on iron metabolism in critically ill patients.

  Boshuizen M, van Hezel M E, van Manen L, Straat M, Somsen Y B O, Spoelstra-de Man A M E, Blumberg N, van Bruggen R and Juffermans N P. Transfusion 2019; 59 (4): 1196-1201. abstract
• Apheresis causes complement deposition on red blood cells (RBCs) and RBC antigen alterations, possibly inducing enhanced clearance.

  de Back D Z, Nezjad S G, Beuger B M, Veldhuis M, Clifford E, Ait Ichou F, Berghuis J, Go M, Gouwerok E, Meinderts S, Vrielink H, de Kort W, de Korte D, van Kraaij M and van Bruggen R. Transfusion 2018; 58 (11): 2627-2634. abstract
• Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis.

  Matlung H L, Babes L, Zhao X W, van Houdt M, Treffers L W, van Rees D J, Franke K, Schornagel K, Verkuijlen P, Janssen H, Halonen P, Lieftink C, Beijersbergen R L, Leusen J H W, Boelens J J, Kuhnle I, van der Werff Ten Bosch J, Seeger K, Rutella S, Pagliara D, Matozaki T, Suzuki E, Menke-van der Houven van Oordt C W, van Bruggen R, Roos D, van Lier R A W, Kuijpers T W, Kubes P and van den Berg T K. Cell Rep 2018; 23 (13): 3946-3959 e6. abstract
• Iron metabolism in critically ill patients developing anemia of inflammation: a case control study.

  Boshuizen M, Binnekade J M, Nota B, van de Groep K, Cremer O L, Tuinman P R, Horn J, Schultz M J, van Bruggen R, Juffermans N P, Molecular Diagnosis and Risk Stratification of Sepsis Consortium. Ann Intensive Care 2018; 8 (1): 56. abstract
• Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations.

  Mock D M, Nalbant D, Kyosseva S V, Schmidt R L, An G, Matthews N I, Vlaar A P J, van Bruggen R, de Korte D, Strauss R G, Cancelas J A, Franco R S, Veng-Pedersen P and Widness J A. Transfusion 2018; 58 (8): 2068-2081. abstract
• Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells.

  D'Alessandro A, Reisz J A, Culp-Hill R, Korsten H, van Bruggen R and de Korte D. Transfusion 2018; 58 (8): 1992-2002. abstract
• Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-gamma receptors.

  Nagelkerke S Q, Bruggeman C W, den Haan J M M, Mul E P J, van den Berg T K, van Bruggen R and Kuijpers T W. Blood Adv 2018; 2 (8): 941-953. abstract
• Transfusion of autologous extracellular vesicles from stored red blood cells does not affect coagulation in a model of human endotoxemia.

  Peters A L, Vlaar A P J, van Bruggen R, de Korte D, Meijers J C M, Nieuwland R and Juffermans N P. Transfusion 2018; 58 (6): 1486-1493. abstract
• A method for red blood cell biotinylation in a closed system.

  de Back D Z, Vlaar R, Beuger B, Daal B, Lagerberg J, Vlaar A P J, de Korte D, van Kraaij M and van Bruggen R. Transfusion 2018; 58 (4): 896-904. abstract
• Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging.

  Klei T R L, de Back D Z, Asif P J, Verkuijlen Pjjh, Veldthuis M, Ligthart P C, Berghuis J, Clifford E, Beuger B M, van den Berg T K, van Zwieten R, El Nemer W and van Bruggen R. Blood Adv 2018; 2 (1): 14-24. abstract
• Non-classical FCGR2C haplotype is associated with protection from red blood cell allo-immunization in sickle cell disease.

  Meinderts S M, Sins J W R, Fijnvandraat K, Nagelkerke S Q, Geissler J, Tanck M W, Bruggeman C, Biemond B J, Rijneveld A W, Kerkhoffs J H, Pakdaman S, Habibi A, van Bruggen R, Kuijpers T W, Pirenne F and van den Berg T K. Blood 2017; 130 (19): 2121-2130. abstract
• Comparison of Spectrophotometry, Chromate Inhibition, and Cytofluorometry Versus Gene Sequencing for Detection of Heterozygously Glucose-6-Phosphate Dehydrogenase-Deficient Females.

  Peters A L, Veldthuis M, van Leeuwen K, Bossuyt P M M, Vlaar A P J, van Bruggen R, de Korte D, Van Noorden C J F and van Zwieten R. J Histochem Cytochem 2017; 65 (11): 627-636. abstract
• Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity.

  Boshuizen M, van der Ploeg K, von Bonsdorff L, Biemond B J, Zeerleder S S, van Bruggen R and Juffermans N P. Blood Rev 2017; 31 (6): 400-405. abstract
• The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response.

  van Hezel M E, Nieuwland R, van Bruggen R and Juffermans N P. Int J Mol Sci 2017; 18 (6): e1285. abstract
• Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells.

  Meinderts S M, Oldenborg P A, Beuger B M, Klei T R L, Johansson J, Kuijpers T W, Matozaki T, Huisman E J, de Haas M, van den Berg T K and van Bruggen R. Blood Adv 2017; 1 (14): 875-886. abstract
• Endotoxemia Results in Trapping of Transfused Red Blood Cells in Lungs with Associated Lung Injury.

  Straat M, Tuip A, Klei T R, Beuger B M, Roelofs J J, van Bruggen R and Juffermans N P. Shock 2017; 48 (4): 484-489. abstract
• Transfusion of 35-day-stored red blood cells does not alter lipopolysaccharide tolerance during human endotoxemia.

  Peters A L, van Hezel M E, Klanderman R B, Tuip-de Boer A M, Wiersinga W J, van der Spek A H, van Bruggen R, de Korte D, Juffermans N P and Vlaar A P. Transfusion 2017; 57 (6): 1359-1368. abstract
• Residual pyruvate kinase activity in PKLR deficient erythroid precursors of a patient suffering from severe haemolytic anaemia.

  Klei T R, Kheradmand Kia S, Veldthuis M, Beuger B M, Geissler J, Dehbozorgian J, Karimi M, van Bruggen R and van Zwieten R. Eur J Haematol 2017; 98 (6): 584-589. abstract
• From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis.

  Klei T R, Meinderts S M, van den Berg T K and van Bruggen R. Front Immunol 2017; 8 73. abstract
• Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury.

  Peters A L, Vervaart M A, van Bruggen R, de Korte D, Nieuwland R, Kulik W and Vlaar A P. Vox Sang 2017; 112 (1): 25-32. abstract
• Monocyte-mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by beta-integrin.

  Straat M, van Hezel M E, Boing A, Tuip-De Boer A, Weber N, Nieuwland R, van Bruggen R and Juffermans N P. Transfusion 2016; 56 (12): 3012-3020. abstract
• Transfusion of 35-day stored red blood cells does not result in increase of plasma non-transferrin bound iron in human endotoxemia.

  Peters A L, Kunanayagam R K, van Bruggen R, de Korte D, Juffermans N P and Vlaar A P. Transfusion 2017; 57 (1): 53-59. abstract
• Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model.

  Peters A L, Beuger B, Mock D M, Widness J A, de Korte D, Juffermans N P, Vlaar A P and van Bruggen R. Transfusion 2016; 56 (6): 1362-9. abstract
• Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans.

  Peters A L, van Hezel M E, Cortjens B, Tuip-de Boer A M, van Bruggen R, de Korte D, Jonkers R E, Bonta P I, Zeerleder S S, Lutter R, Juffermans N P and Vlaar A P. Crit Care Med 2016; 44 (6): e412-9. abstract
• Accelerated clearance of human red blood cells in a rat transfusion model.

  Straat M, Klei T, de Korte D, van Bruggen R and Juffermans N P. Intensive Care Med Exp 2015; 3 (1): 27. abstract
• Loss of CD47 Makes Dendritic Cells See Red.

  van den Berg T K and van Bruggen R. Immunity 2015; 43 (4): 622-4. abstract
• Glucose-6-phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells.

  Peters A L, van Bruggen R, de Korte D, Van Noorden C J and Vlaar A P. Transfusion 2016; 56 (2): 427-32. abstract
• Intrinsic defects in erythroid cells from familial hemophagocytic lymphohistiocytosis type 5 patients identify a role for STXBP2/Munc18-2 in erythropoiesis and phospholipid scrambling.

  Kostova E B, Beuger B M, Veldthuis M, van der Werff Ten Bosch J, Kuhnle I, van den Akker E, van den Berg T K, van Zwieten R and van Bruggen R. Exp Hematol 2015; 43 (12): 1072-1076.e2. abstract
• Identification of signalling cascades involved in red blood cell shrinkage and vesiculation.

  Kostova E B, Beuger B M, Klei T R, Halonen P, Lieftink C, Beijersbergen R, van Den Berg T K and van Bruggen R. Bioscience reports 2015; 35 (2): . abstract
• Differential Complement Activation Pathways Promote C3b Deposition on Native and Acetylated LDL thereby Inducing Lipoprotein Binding to the Complement Receptor.

  Klop B, van der Pol P, van Bruggen R, Wang Y, de Vries M A, van Santen S, O'Flynn J, van de Geijn G J, Njo T L, Janssen H W, de Man P, Jukema J W, Rabelink T J, Rensen P C, van Kooten C and Castro Cabezas M. The Journal of biological chemistry 2014; 289 (51): 35421-30. abstract
• Plasmodium falciparum malaria and invasive bacterial co-infection in young African children: the dysfunctional spleen hypothesis.

  Gomez-Perez GP, van Bruggen R, Grobusch MP and Dobano C. Malar J 2014; 13 (1475-2875 (Linking)): 335. abstract
• Of macrophages and red blood cells; a complex love story.

  de Back DZ, Kostova EB, van Kraaij M, van den Berg TK and van Bruggen R. Front Physiol 2014; 5 9 (1-11). abstract
• Hereditary spherocytosis due to band 3 deficiency: 15 novel mutations in SLC4A1.

  van Zwieten R, Francois JJ, van Leeuwen K, Van Wesel AC, van Bruggen R, Van Solinge WW, Roos D, Verhoeven AJ and van Wijk R. Am J Hematol 2013; 88 (0361-8609 (Linking)): 159-160. abstract
• Potassium leakage primes stored erythrocytes for phosphatidylserine exposure and shedding of pro-coagulant vesicles.

  Burger P, Kostova E, Bloem E, Hilarius-Stokman P, Meijer AB, van den Berg TK, Verhoeven AJ, de Korte D and van Bruggen R. Br J Haematol 2013; 160 (0007-1048 (Linking)): 377-386. abstract
• SIRPalpha Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91(phox).

  van Beek EM, Alvarez Zarate J, van Bruggen R, Schornagel K, Tool AT, Matozaki T, Kraal G, Roos D and van den Berg TK. Cell Rep 2012; 2 (2211-1247 (Electronic)): 748-755. abstract
• The cholesterol content of the erythrocyte membrane is an important determinant of phosphatidylserine exposure.

  van Zwieten R, Bochem AE, Hilarius PM, van Bruggen R, Bergkamp F, Hovingh GK and Verhoeven AJ. Biochim Biophys Acta 2012; 1821 (0006-3002 (Linking)): 1493-1500. abstract
• Prevention of Non-immune Mediated Transfusion-related Acute Lung Injury; from Blood Bank to Patient.

  van Bruggen R and de Korte D. Curr Pharm Des 2012; 18 (1381-6128 (Linking)): 3249-3254. abstract
• CD47 functions as a molecular switch for erythrocyte phagocytosis.

  Burger P, Hilarius-Stokman P, de Korte D, van den Berg TK and van Bruggen R. Blood 2012; 119 (0006-4971 (Linking)): 5512-5521. abstract
• Collection and storage of red blood cells with anticoagulant and additive solution with a physiologic pH.

  Burger P, Korsten H, Verhoeven AJ, de Korte D and van Bruggen R. Transfusion 2012; 52 (0041-1132 (Linking)): 1245-1252. abstract
• CD47 in Erythrocyte Ageing and Clearance - the Dutch Point of View.

  Burger P, de Korte D, van den Berg TK and van Bruggen R. Transf Med Hemother 2012; 39 348-352.
• Red Blood Cell Clearance in Inflammation.

  Straat M, van Bruggen R, de Korte D and Juffermans NP. Transf Med Hemother 2012; 39 353-360.
• Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent.

  Vlaar AP, Kulik W, Nieuwland R, Peters CP, Tool AT, van Bruggen R, Juffermans NP and de Korte D. Transfusion 2011; 51 (0041-1132 (Linking)): 2358-2366. abstract
• Toll-Like Receptor Responses in IRAK-4-Deficient Neutrophils.

  van Bruggen R, Drewniak A, Tool AT, Jansen M, van Houdt M, Geissler J, van den Berg TK, Chapel H and Kuijpers TW. J Innate Immun 2010; 2 (3): 280-287. abstract
• An improved red blood cell additive solution maintains 2,3-diphosphoglycerate and adenosine triphosphate levels by an enhancing effect on phosphofructokinase activity during cold storage.

  Burger P, Korsten H, de Korte D, Rombout E, van Bruggen R and Verhoeven AJ. Transfusion 2010; 50 (11): 2386-2392. abstract
• Human NLRP3 inflammasome activation is Nox1-4 independent.

  van Bruggen R, Koker MY, Jansen M, van Houdt M, Roos D, Kuijpers TW and van den Berg TK. Blood 2010; 115 (26): 5398-5400. abstract
• Toll-like receptor-induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes.

  Drewniak A, Tool AT, Geissler J, van Bruggen R, van den Berg TK and Kuijpers TW. Blood 2010; 115 (22): 4588-4596. abstract
• Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles.

  van Bruggen R, Drewniak A, Jansen M, van Houdt M, Roos D, Chapel H, Verhoeven AJ and Kuijpers TW. Mol Immunol 2009; 47 (2-3): 575-581. abstract
• The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria.

  Fabriek BO, van Bruggen R, Deng DM, Ligtenberg AJ, Nazmi K, Schornagel K, Vloet RP, Dijkstra CD and van den Berg TK. Blood 2009; 113 (4): 887-892. abstract
• Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.

  Dostert C, Petrilli V, van Bruggen R, Steele C, Mossman BT and Tschopp J. Science 2008; 320 (5876): 674-677. abstract
• Natural history and early diagnosis of LAD-1/variant syndrome.

  Kuijpers TW, van Bruggen R, Kamerbeek N, Tool AT, Hicsonmez G, Gurgey A, Karow A, Verhoeven AJ, Seeger K, Sanal O, Niemeyer C and Roos D. Blood 2007; 109 (8): 3529-3537. abstract
• Growth factors G-CSF and GM-CSF differentially preserve chemotaxis of neutrophils aging in vitro.

  Wolach B, van der Laan LJ, Maianski NA, Tool AT, van Bruggen R, Roos D and Kuijpers TW. Exp Hematol 2007; 35 (4): 541-550. abstract
• Complement Receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella by human neutrophils.

  van Bruggen R, Zweers D, van Diepen A, van Dissel JT, Roos D, Verhoeven AJ and Kuijpers TW. Infect Immun 2007; 75 (6): 2655-2660. abstract
• The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.

  Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ and Hamann J. J Leukoc Biol 2007; 81 (2): 440-448. abstract
• Single-cell optical imaging of the phagocyte NADPH oxidase.

  van Manen HJ, van Bruggen R, Roos D and Otto C. Antioxid Redox Signal 2006; 8 (9-10): 1509-1522. abstract
• Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells.

  Bionda C, Li XJ, van Bruggen R, Eppink M, Roos D, Morel F and Stasia MJ. Hum Genet 2004; 115 (5): 418-427. abstract
• Continuous translocation of Rac2 and the NADPH oxidase component p67(phox) during phagocytosis.

  van Bruggen R, Anthony E, Fernandez-Borja M and Roos D. J Biol Chem 2004; 279 (10): 9097-9102. abstract
• Built for the kill : studies on the neutrophil NADPH oxidase.

  van Bruggen R. University of Amsterdam, Amsterdam, April 28, 2004;
• Oxidative killing of microbes by neutrophils.

  Roos D, van Bruggen R and Meischl C. Microbes Infect 2003; 5 (14): 1307-1315. abstract
• Resonance Raman imaging of the NADPH oxidase subunit cytochrome b558 in single neutrophilic granulocytes.

  van Manen HJ, Uzunbajakava N, van Bruggen R, Roos D and Otto C. J Am Chem Soc 2003; 125 (40): 12112-12113. abstract
• Calcium signalling is altered in myeloid cells with a deficiency in NADPH oxidase activity.

  Rada BK, Geiszt M, van Bruggen R, Nemet K, Roos D and Ligeti E. Clin Exp Immunol 2003; 132 (1): 53-60. abstract
• Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.

  van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gomez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ and Roos D. Blood 2002; 100 (3): 1026-1030. abstract
• Genetic analysis of patients with chronic granulomatous disease: insights in a clinical situation.

  Roos D and van Bruggen R. Centr Eur J Immunol 2000; 25 (3): 106-112.