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Rick (R) Kapur

Training

Biology/Biomedical Sciences (BSc, MSc), Medicine (MD), Immunohematology (PhD).

Thesis

"Multifactorial Aspects of Antibody-Mediated Blood Cell Destruction". (2014; ISBN: 978-90-5335-806-1). Full text: UVA

 

Research interests

Dissection of pathophysiological mechanisms in Transfusion Medicine, with focus on Transfusion-related acute lung injury (TRALI), antibody-mediated hematological disorders including immune thrombocytopenia (ITP), fetal and neonatal alloimmune thrombocytopenia (FNAIT), hemolytic disease of the fetus and newborn (HDFN). Additional interests include immune functions of platelets.

Technology

Experimental mouse models, diverse immunological assays including phagocytosis and respiratory burst assays.

Resume

2019 - present

Researcher at Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

2017 - 2019

Post-doctoral fellow at Lund University, Lund, Sweden.

2015 - 2017

Post-doctoral fellow at Canadian Blood Services, Toronto Platelet Immunobiology Group, Keenan Research Center for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

2009-2014

PhD at Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Thesis: “Multifactorial Aspects of Antibody-Mediated Blood Cell Destruction”. Supervisor: Prof. Dr. C.E. van der Schoot. Co-supervisor: Dr. G. Vidarsson.

2004-2008

MD at SUMMA (Selective Utrecht Medical Masters), University Medical Center Utrecht, Utrecht University, The Netherlands.

1998-2004

BSc and MSc in Biology with specialization in Fundamental Biomedical Sciences, Faculty of Biology, Utrecht University, The Netherlands.

Other publications

  • Rebetz J, Semple JW and KAPUR R. The pathogenic involvement of neutrophils in Acute Respiratory Distress Syndrome (ARDS) and Transfusion-related acute lung injury (TRALI). Transfus Med Hemother. 2018 Oct;45(5):290-298.
  • Semple JW, Rebetz J and KAPUR R. Transfusion-associated circulatory overload (TACO): Time to shed light on the pathophysiology. ISBT Science Series 2018; in press.
  • Semple JW and KAPUR R.  Moving target PF4 directs HIT responses. Blood. 2018 Aug 16;132(7):678-679. Editorial.
  • KAPUR R, Kim M, Rebetz J, Hallström B, Björkman JT, Takabe-French A, Kim N, Liu J, Shanmugabhavananthan S, Milosevic S, McVey MJ, Speck ER, Semple JW.  Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury. Blood Adv. 2018 Jul 10;2(13):1651-1663.
  • Guo L*, KAPUR R*, Aslam R, Hunt K, Hou Y, Zufferey A, Speck ER, Rondina MT, Lazarus AH, Ni H, Semple JW. Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia. Scand J Immunol. 2018 Jul;88(1):e12678. * Equally contributed.
  • Semple JW, McVey MJ, Kim M, Rebetz J, Kuebler WM and KAPUR R.  Targeting Transfusion-Related Acute Lung Injury: The Journey from Basic Science to Novel Therapies. Crit Care Med. 2018 May;46(5):e452-e458. doi.
  • KAPUR R, Semple JW. Platelet Immunobiology: platelets as prey and predator. ISBT Science Series 2018;13:87-92.
  • KAPUR R*, Catalina MD*, Aslam R, Speck ER, Francovitch R, Semple JW. A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP). Br J Haematol. 2018 Nov;183(3):501-503.. * Equally contributed.
  • Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, KAPUR R, Boilard E, Italiano Jr, JE, Semple JW. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Adv. 2017 Sep 8;1(20):1773-1785.
  • KAPUR R, Kim M, Rebetz J, Rondina MT, Porcelijn L, Semple JW. Low Levels of Interleukin-10 in Patients with Transfusion-Related Acute Lung Injury.  2017 Aug;5(16):339.
  • Zufferey A, KAPUR R, Semple JW. Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). J Clin Med. 2017 Feb 9;6(2).
  • KAPUR R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER, Zufferey A, Yousef G, Zhang H, Rondina MT, Weyrich AS, Porcelijn L, Kuebler WM, Slutsky AS, Semple JW.T Regulatory Cells and Dendritic Cells Protect Against Transfusion-Related Acute Lung Injury via IL-10. Blood. 2017 May 4;129(18):2557-2569.
  • KAPUR R, Aslam A, Kim A, Guo L, Ni H, Segel GB, Semple JW. Thymic-derived tolerizing dendritic cells are up-regulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia. Platelets. 2017 Jul;28(5):521-524.    
  • KAPUR R, Semple JW. Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2.  2016 Dec;4(24):488. Editorial.
  • KAPUR R, Semple JW. Platelets as immune-sensing cells.  2016 Nov 22;1(1):10-14.                                                                                                                                  
  • KAPUR R, Kim M, Rondina MT, Porcelijn L, Semple JW. Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury.  2016 Nov  22;7(47):78048-78054.                                                                                                   
  • Aslam R*, KAPUR R*, Segel GB, Guo L, Zufferey A, Ni H, Semple JW. The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia.  2016 Oct;44(10):924-930. * Equally contributed.
  • KAPUR R, Semple JW. The nonhemostatic immune functions of platelets.  2016 Apr;53 Suppl 1:S2-6.  
  • Guo L, KAPUR R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW. CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia.  2016 Feb 11;127(6):735-8.
  • KAPUR R, Kim M, Shanmugabhavananthan S, Liu J, Li Y, Semple JW. C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury (TRALI).  2015 Dec 17;126(25):2747-51
  • KAPUR R, Zufferey A, Boilard E, Semple JW. Nouvelle cuisine: platelets served with inflammation.  2015 Jun 15;194(12):5579-87.
  • KAPUR R, Stramrood CA, Schutgens RE, van Asbeck BS. Cyproterone acetate- and ethinyloestradiol-containing oral contraceptive as a risk factor for upper extremity deep venous thrombosis-a case report.  2009 Apr;14(2):160-3.
  • KAPUR R, Ebeling S, Hagenbeek A. B-cell involvement in chronic graft-versus-host disease.  2008 Nov;93(11):1702-11. 
  • Chandra S, Levran O, Jurickova I, Maas C, KAPUR R, Schindler D, Henry R, Milton K, Batish SD, Cancelas JA, Hanenberg H, Auerbach AD, Williams DA. A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.  2005 Nov;12(5):976-84
  • Verwaal R, Arako M, KAPUR R, Verkleij AJ, Verrips CT, Boonstra J. HXT5 expression is under control of STRE and HAP elements in the HXT5 promoter.  2004 Jul 15;21(9):747-57.