Publications

• N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP.

  Ercig B, Gomes Graca N A, Kangro K, Arfman T, Wichapong K, Hrdinova J, Kaijen P, van Alphen F, van den Biggelaar M, Vanhoorelbeke K, Veyradier A, Coppo P, Reutelingsperger C, Nicolaes G A F, Mannik A and Voorberg J. Blood 2021; epub ahead of print FEb 5, 2020. abstract
• Hydrogen-Deuterium Exchange Mass Spectrometry Identifies Activated Factor IX-Induced molecular Changes in Activated Factor VIII.

  van Galen J, Freato N, Przeradzka M A, Ebberink Ehtm, Boon-Spijker M, van der Zwaan C, van den Biggelaar M and Meijer A B. Thromb Haemost 2020; epub ahead of print Dec 10, 2020. abstract
• Factor VIII-driven changes in activated Factor IX explored by Hydrogen-Deuterium eXchange Mass Spectrometry.

  Freato N, Ebberink E H T M, van Galen J, Fribourg C, Boon-Spijker M, van Alphen F, Meijer A B, van den Biggelaar M and Mertens K. Blood 2020; 136 (23): 2703-2714. abstract
• Flow-induced Reorganization of Laminin-integrin Networks Within the Endothelial Basement Membrane Uncovered by Proteomics.

  Beguin E P, Janssen E F J, Hoogenboezem M, Meijer A B, Hoogendijk A J and van den Biggelaar M. Mol Cell Proteomics 2020; 19 (7): 1179-1192. abstract
• GPA33: A Marker to Identify Stable Human Regulatory T Cells.

  Opstelten R, de Kivit S, Slot M C, van den Biggelaar M, Iwaszkiewicz-Grzes D, Gliwinski M, Scott A M, Blom B, Trzonkowski P, Borst J, Cuadrado E and Amsen D. J Immunol 2020; 204 (12): 3139-3148. abstract
• Flow-induced reorganization of laminin-integrin networks within the endothelial basement membrane uncovered by proteomics.

  Beguin E P, Janssen E F J, Hoogenboezem M, Meijer A B, Hoogendijk A J and van den Biggelaar M. Mol Cell Proteomics 2020; 19 (7): 1179-1192. abstract
• CD29 identifies IFN-gamma-producing human CD8(+) T cells with an increased cytotoxic potential.

  Nicolet B P, Guislain A, van Alphen F P J, Gomez-Eerland R, Schumacher T N M, van den Biggelaar M and Wolkers M C. Proc Natl Acad Sci U S A 2020; 117 (12): 6686-6696. abstract
• The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.

  Hansen M, Zeddies S, Meinders M, di Summa F, van Alphen F P J, Hoogendijk A J, Moore K S, Halbach M, Gutierrez L, van den Biggelaar M, Thijssen-Timmer D C, Auburger G W J, van den Akker E, von Lindern M and Rollmann E. Int J Mol Sci 2020; 21 (3): . abstract
• Unique surface-exposed hydrophobic residues in the C1 domain of Factor VIII contribute to cofactor function and Von Willebrand Factor binding.

  Przeradzka M A, Freato N, Boon-Spijker M, van Galen J, van der Zwaan C, Mertens K, van den Biggelaar M and Meijer A B. J Thromb Haemost 2020; 18 (2): 364-372. abstract
• Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming.

  Hoogendijk A J, Pourfarzad F, Aarts C E M, Tool A T J, Hiemstra I H, Grassi L, Frontini M, Meijer A B, van den Biggelaar M and Kuijpers T W. Cell Rep 2019; 29 (8): 2505-2519 e4. abstract
• Alternative trafficking of Weibel-Palade body proteins in CRISPR/Cas9-engineered von Willebrand factor-deficient blood outgrowth endothelial cells.

  Schillemans M, Kat M, Westeneng J, Gangaev A, Hofman M, Nota B, van Alphen F P J, de Boer M, van den Biggelaar M, Margadant C, Voorberg J and Bierings R. Res Pract Thromb Haemost 2019; 3 (4): 718-732. abstract
• High-Throughput Assessment of Kinome-wide Activation States.

  Schmidlin T, Debets D O, van Gelder Cagh, Stecker K E, Rontogianni S, van den Eshof B L, Kemper K, Lips E H, van den Biggelaar M, Peeper D S, Heck A J R and Altelaar M. Cell Syst 2019; 9 (4): 366-374.e5. abstract
• D'domain Region Arg782-Cys799 of Von Willebrand Factor contributes to Factor VIII binding.

  Przeradzka M A, van Galen J, Ebberink E HTM, Hoogendijk A J, van der Zwaan C, Mertens K, van den Biggelaar M and Meijer A B. Haematologica 2020; 105 (6): 1695-1703. abstract
• Interaction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells.

  Schillemans M, Karampini E, Hoogendijk A J, Wahedi M, van Alphen F P J, van den Biggelaar M, Voorberg J and Bierings R. J Proteomics 2019; 205 103417. abstract
• Endocytosis by macrophages: Interplay of macrophage scavenger receptor-1 and LDL receptor-related protein-1.

  Beguin E P, Przeradzka M A, Janssen E F J, Meems H, Sedek M, van der Zwaan C, Mertens K, van den Biggelaar M, Meijer A B and Mourik M J. Haematologica 2020; 105 (3): e133-e137. abstract
• Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.

  Karampini E, Schillemans M, Hofman M, van Alphen F, de Boer M, Kuijpers T W, van den Biggelaar M, Voorberg J and Bierings R. Haematologica 2019; 104 (10): 2091-2099. abstract
• The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.

  Hsiao C C, Chu T Y, Wu C J, van den Biggelaar M, Pabst C, Hebert J, Kuijpers T W, Scicluna B P, I K Y, Chen T C, Liebscher I, Hamann J and Lin H H. Front Immunol 2018; 9 2830. abstract
• The D' domain of von Willebrand factor requires the presence of the D3 domain for optimal factor VIII binding.

  Przeradzka M A, Meems H, van der Zwaan C, Ebberink E H T M, van den Biggelaar M, Mertens K and Meijer A B. Biochem J 2018; 475 (17): 2819-2830. abstract
• Integrated proteomic analysis of tumor necrosis factor alpha and interleukin 1beta-induced endothelial inflammation.

  Beguin E P, van den Eshof B L, Hoogendijk A J, Nota B, Mertens K, Meijer A B and van den Biggelaar M. J Proteomics 2019; 192 89-101. abstract
• Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells.

  Salerno F, Engels S, van den Biggelaar M, van Alphen F P J, Guislain A, Zhao W, Hodge D L, Bell S E, Medema J P, von Lindern M, Turner M, Young H A and Wolkers M C. Nat Immunol 2018; 19 (8): 828-837. abstract
• The Weibel-Palade Body Localized SNARE (Soluble NSF Attachment Protein Receptor) Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells.

  Schillemans M, Karampini E, van den Eshof B, Gangaev A, Hofman M, van Breevoort D, Meems H, Janssen H, Mulder A A, Jost C R, Escher J C, Adam R, Carter T, Koster A J, van den Biggelaar M, Voorberg J and Bierings R. Arterioscler Thromb Vasc Biol 2018; 38 (7): 1549-1561. abstract
• Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity.

  Cuadrado E, van den Biggelaar M, de Kivit S, Chen Y Y, Slot M, Doubal I, Meijer A, van Lier R A W, Borst J and Amsen D. Immunity 2018; 48 (5): 1046-1059 e6. abstract
• Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages.

  Heideveld E, Hampton-O'Neil L A, Cross S J, van Alphen F P J, van den Biggelaar M, Toye A M and van den Akker E. Haematologica 2018; 103 (3): 395-405. abstract
• Differences between Platelets Derived from Neonatal Cord Blood and Adult Peripheral Blood Assessed by Mass Spectrometry.

  Stokhuijzen E, Koornneef J M, Nota B, van den Eshof B L, van Alphen F P J, van den Biggelaar M, van der Zwaan C, Kuijk C, Mertens K, Fijnvandraat K and Meijer A B. J Proteome Res 2017; 16 (10): 3567-3575. abstract
• Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics.

  van den Eshof B L, Hoogendijk A J, Simpson P J, van Alphen F P J, Zanivan S, Mertens K, Meijer A B and van den Biggelaar M. Arterioscler Thromb Vasc Biol 2017; 37 (10): 1891-1902. abstract
• Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells.

  van Aalderen M C, van den Biggelaar M, Remmerswaal E B M, van Alphen F P J, Meijer A B, Ten Berge I J M and van Lier R A W. Cell Rep 2017; 19 (5): 1068-1079. abstract
• Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

  Hernandez-Fernaud J R, Ruengeler E, Casazza A, Neilson L J, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson I R, McNeish I, Ennis D, Ali H, Kugeratski F G, Al Khamici H, van den Biggelaar M, van den Berghe P V, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela S M, Blyth K, Yin H, Mazzone M, Norman J C and Zanivan S. Nat Commun 2017; 8 14206. abstract
• Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).

  de Nardis C, Lossl P, van den Biggelaar M, Madoori P K, Leloup N, Mertens K, Heck A J and Gros P. J Biol Chem 2017; 292 (3): 912-924. abstract
• Hepatitis B Virus Protein X Induces Degradation of Talin-1.

  van de Klundert M A, van den Biggelaar M, Kootstra N A and Zaaijer H L. Viruses 2016; 8 (10): 1-17. abstract
• Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components.

  Gazendam R P, van de Geer A, van Hamme J L, Tool A T, van Rees D J, Aarts C E, van den Biggelaar M, van Alphen F, Verkuijlen P, Meijer A B, Janssen H, Roos D, van den Berg T K and Kuijpers T W. Haematologica 2016; 101 (5): 587-96. abstract
• Factor VIII Interacts with the Endocytic Receptor Low-Density Lipoprotein Receptor-Related Protein 1 via an Extended Surface Comprising 'Hot-Spot' Lysine Residues.

  van den Biggelaar M, Madsen J J, Faber J H, Zuurveld M G, van der Zwaan C, Olsen O H, Stennicke H R, Mertens K and Meijer A B. J Biol Chem 2015; 290 (27): 16463-76. abstract
• A novel chemical foot printing approach identifies critical lysine residues involved in the binding of receptor-associated-protein to cluster II of LDL receptor-related protein.

  Bloem E, Ebberink E H, van den Biggelaar M, van der Zwaan C, Mertens K and Meijer A B. The Biochemical journal 2015; 468 (1): 65-72. abstract
• Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells.

  van den Biggelaar M, Hernandez-Fernaud JR, van den Eshof BL, Neilson LJ, Meijer AB, Mertens K and Zanivan S. Blood 2014; 123 (12): e22-e36. abstract
• The effect of shiga toxin on weibel-palade bodies in primary human endothelial cells.

  Geelen J, van den Biggelaar M, Linssen P, van der Velden T, Mertens K and Monnens L. Nephron Extra 2014; 4 (1664-5529 (Electronic)): 101-107. abstract
• Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis.

  McGrath RT, van den Biggelaar M, Byrne B, O'Sullivan JM, Rawley O, O'Kennedy R, Voorberg J, Preston RJ and O'Donnell JS. Blood 2013; 122 (0006-4971 (Linking)): 4107-4110. abstract
• Factor VIII C1-domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

  Bloem E, van den Biggelaar M, Wroblewska A, Voorberg J, Faber JH, Kjalke M, Stennicke HR, Mertens K and Meijer AB. J Biol Chem 2013; 288 (0021-9258 (Linking)): 29670-29679. abstract
• A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

  Bloem E, Meems H, van den Biggelaar M, Mertens K and Meijer AB. J Biol Chem 2013; 288 (0021-9258 (Linking)): 26105-26111. abstract
• Distinct roles of Ser764 and Lys773 at the N-terminus of von Willebrand factor for complex assembly with coagulation factor VIII.

  Castro-Nunez L, Bloem E, Boon-Spijker MG, van der Zwaan C, van den Biggelaar M, Mertens K and Meijer AB. J Biol Chem 2013; 288 (0021-9258 (Linking)): 393-400. abstract
• Factor VIII variants having a decreased cellular uptake.

  Meems H, Meijer AB, Mertens K, Olsen Hvilsted O, Lamberth K, Noerby Lisby P, Johnsen Bruun L, Kjalke Hjortnaes M, Stennicke HR, Voorberg J and van den Biggelaar M. 2013; 
• Establishment of outgrowth endothelial cells from peripheral blood.

  Martin-Ramirez J, Hofman M, van den Biggelaar M, Hebbel RP and Voorberg J. Nat Protoc 2012; 7 (1750-2799 (Linking)): 1709-1715. abstract
• Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice.

  Wroblewska A, van Haren SD, Herczenik E, Kaijen P, Ruminska A, Jin SY, Zheng XL, van den Biggelaar M, ten Brinke A, Meijer AB and Voorberg J. Blood 2012; 119 (0006-4971 (Linking)): 5294-5300. abstract
• Mass spectrometry-assisted study reveals that lysine residues 1967 and 1968 have opposite contribution to stability of activated factor VIII.

  Bloem E, Meems H, van den Biggelaar M, van der Zwaan C, Mertens K and Meijer AB. J Biol Chem 2012; 287 (0021-9258 (Linking)): 5775-5783. abstract
• Reply.

  Herczenik E, van Haren SD, Wroblewska A, Kaijen P, van den Biggelaar M, Meijer AB, ten Brinke A and Voorberg J. J Allergy Clin Immunol 2012; 129 (0091-6749 (Linking)): 1174-1175. abstract
• Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain.

  Herczenik E, van Haren SD, Wroblewska A, Kaijen P, van den Biggelaar M, Meijer AB, Martinez-Pomares L, ten Brinke A and Voorberg J. J Allergy Clin Immunol 2012; 129 (0091-6749 (Linking)): 501-509 e5. abstract
• Factor VIII alters tubular organization and functional properties of Von Willebrand factor stored in Weibel-Palade bodies.

  Bouwens EA, Mourik MJ, van den Biggelaar M, Eikenboom JC, Voorberg J, Valentijn KM and Mertens K. Blood 2011; 118 (0006-4971 (Linking)): 5947-5956. abstract
• C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII.

  Meems H, van den Biggelaar M, Rondaij M, van der Zwaan C, Mertens K and Meijer AB. Int J Biochem Cell Biol 2011; 43 (1357-2725 (Linking)): 1114-1121. abstract
• A single lysine of the two-lysine recognition motif of the D3 domain of receptor associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein.

  van den Biggelaar M, Sellink E, Klein Gebbinck JW, Mertens K and Meijer AB. Int J Biochem Cell Biol 2011; 43 (1357-2725 (Linking)): 431-440. abstract
• Storage of Factor VIII Variants with Impaired von Willebrand Factor Binding in Weibel-Palade Bodies in Endothelial Cells.

  van den Biggelaar M, Bouwens EA, Voorberg J and Mertens K. PLoS ONE 2011; 6 (1932-6203 (Linking)): e24163. abstract
• Intracellular co-trafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles.

  van den Biggelaar M, Meijer AB, Voorberg J and Mertens K. Blood 2009; 113 (13): 3102-3109. abstract
• Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells.

  van den Biggelaar M, Bouwens EA, Kootstra NA, Hebbel RP, Voorberg J and Mertens K. Haematologica 2009; 94 (5): 670-678. abstract
• Factor VIII trafficking to Weibel-Palade bodies [De route van factor VIII naar Weibel-Palade bodies].

  van den Biggelaar M. University of Utrecht, Utrecht, August 27, 2008;
• Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies.

  van den Biggelaar M, Bierings R, Storm G, Voorberg J and Mertens K. J Thromb Haemost 2007; 5 (11): 2235-2243. abstract
• Efficiency of von Willebrand factor-mediated targeting of IL-8 into Weibel-Palade bodies.

  Bierings R, van den Biggelaar M, Kragt A, Mertens K, Voorberg J and van Mourik JA. J Thromb Haemost 2007; 5 (12): 2512-2519. abstract