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Bleeding and hemostasis

Research agenda

Lines of research

I Coagulation proteins: congenital and acquired
In this line of research, the Sanquin investigators focus mainly on the coagulation proteins factor VIII, factor IX, von Willebrand factor, factor XI and ADAMTS13. As a result of this research, we are learning more about the function and interaction of these proteins with other proteins, with cells in the blood vessels and about efficacy and adverse reactions. Besides studying the properties of these proteins, Sanquin investigators are also occupied with the development of new variants of these proteins for the treatment of patients with coagulation disorders. These new variants have a longer half-life or are less immunogenic for instance, so that patients who are treated with these proteins suffer less and benefit more from the treatment. Studies in this research line also focus on the development of new products for treatment of bleeding in patients using anticoagulation.

II Thrombocytopenia and thrombopathy
This research line focuses on i) the formation of thrombocytes under various circumstances in the bone marrow and in the lab, ii) the functions and consequences of anomalies, both in the number and function of thrombocytes, iii) diagnosing and therapy of thrombocytopenia and thrombopathy, iv) optimising safety and storage conditions of thrombocytes, v) the antibody-mediated destruction of thrombocytes and vi) optimising thrombocyte transfusion strategies by means of comparative studies in patients with various medical conditions.

III Surgery and trauma
Investigation in this research line is focused on understanding and therefore preventing or improving the treatment of patients with a disturbed coagulation as a result of an operation, trauma or childbirth. For this we try to find the most efficient combination of tests and therapies befitting the principles of personalised medicine.

National Science Agenda cluster question

The NSA cluster questions shown below are linked to Sanquin’s research lines for the medical need Bleeding and hemostasis.

I.    Coagulation proteins: congenital and acquired
II.    Thrombocytopenia and thrombopathy
III.    Surgery and trauma

77 What is the contribution of non-genetic factors to personal characteristics and disease processes? I, II, III
81 How will the knowledge of genetics play a role in the understanding of, screening for and treatment of (rare) illnesses? I, II, III
91 Pregnancy, giving birth to a child and the menopause: can we improve these? I, II, III
94 How do we make healthcare as qualitatively good as possible, yet keeping it affordable? I, II, III
95 How can healthcare be focused on the uniqueness of a person, amongst other things by making use of biomarkers? I, II, III
98 How can we convert breakthroughs in basic biomedical research better into the development of new drugs?    I, II, III
99 Using a better understanding of life, how can we identify new targets for molecular therapy, antibiotics and antiviral drugs? I, II, III
100 Using (stem) cells and biomaterials, how can we promote the formation and recovery of tissues and organs? I, II, III
101 Can we develop models of the human body and use smart technology for health, food and toxicities research while simultaneously reducing the use of experimental animals drastically? I, II, III
102 How can we develop new medicines and therapies in order to remain as vigorous and healthy as possible? I, II, III
104 How do we develop minimally invasive techniques and interventions for the diagnosis, prognosis and treatment of patients? I, II, III
105 How can big data and technological innovation (e-health) contribute to healthcare? I, II, III
112 Big data: can we utilise big datasets and their gathering for the realisation of values, gaining insights and obtaining answers? I, II, III
122 Can we construct a synthetic cell? II
135 How can we understand the properties, the functionalities and the interaction of molecules in living systems better and, for instance, in this way develop systems that are inspired by life? I, II, III
136 Cells are the building blocks of life. How do they work and what can they teach us about the processes of life? I, II, III