Problems and questions from clinic and practice
Blood contains platelets and a large number of proteins that ensure that blood remains liquid inside the bloodstream and coagulates outside the bloodstream (hemostasis). These components work constantly to adjust the equilibrium between the solid and liquid state of the blood, depending on the needs of the moment. Unfortunately that still can often go wrong. This can cause coagulation problems in patients, including amongst others serious bleeding after childbirth, extensive traumas or operations, sepsis, diffuse intravascular coagulation, hemophilia, von Willebrand disease, idiopathic thrombocytopenic purpura, Glanzmann disease, thrombophilia with cancer, deep vein thrombosis and pulmonary embolism.
The question is what exactly is happening in these patients? What goes wrong in these patients and why, and what can we do to prevent it from happening? The answers to these questions will lead to prevention and/or improvement of the treatment of patients with the aforementioned problems.
Solutions: Sanquin products and services
Donor blood is seperated into three components: red blood cells, platelets and plasma. The various coagulation proteins from the donor plasma are processed into products separately or in combination. Depending on the daignosis, patients with coagulation problems are treated with one blood component or a combination of blood components. In addition to increasing the knowledge required to adjust the treatment strategies as well as possible to the need of each unique patient, and supplying the required products, Sanquin contributes in converting this knowledge into decision-supporting instruments (standards, guidelines, decision making, product leaflets), and disseminating this knowledge through educating (individually, courses, congresses, symposia) patients and healthcare professionals, supporting home treatment of patients with chronic coagulation disorders, diagnosing patients with coagulation disorders, and keeping up a knowledge centre on hemostasis.
Prof Anske van der Bom MD PhD
Blood-borne Infections (Prof Hans Zaaijer MD PhD)
Cell adhesion and migration (Coert Margadant PhD)
Cellular Hemostasis (Prof Jan Voorberg PhD)
Control of erythropoiesis and megakaryopoiesis by environmental factors (Marieke von Lindern PhD)
Epidemiology of transfusion medicine (Prof Anske van der Bom MD PhD)
Immunoglobulin Research (Gestur Vidarsson PhD)
Trafficking and secretion in the vasculature (Ruben Bierings PhD)
Methodology of etiologic clinical transfusion research (Rutger Middelburg PhD)
Molecular Hemostasis (Prof Joost Meijers MD PhD)
Pediatric Hematology (Prof Karin Fijnvandraat MD PhD)
Phagocyte Laboratory (Prof Timo van den Berg PhD, Prof Taco Kuijpers MD PhD)
Plasma Proteins & Research Facilities (Maartje van den Biggelaar PhD)
Proteomics and biomolecular mass spectrometry of hemostatic processes (Prof Sander Meijer PhD)
Transfusion support in cancer therapies (Prof Jaap Jan Zwaginga MD PhD)
Transfusion Technology Assessment (Mart Janssen PhD)
Translational Immunohematology (Prof Masja de Haas MD PhD)