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Prof Jaap (J. D.) van Buul PhD

Training

Cell Biology and Biochemistry

Thesis

 

'Signalling in leukocyte transendothelial migration: a roadmap for homing of progenitor cells'May 2004 - University of Amsterdam

 

Research interests

Signalling pathways that facilitate leukocyte passage across endothelial monolayers. The current focus is directed to small GTPases, such as Rac1, RhoA and RhoG that play an important role in the integrity of the endothelial monolayer.

Technology

  • Molecular and Cell Biology techniques such as cloning, culturing cells, transfections
    Confocal laser scanning microscopy in 4D (3D in time)
  • Classical biochemistry assays such as pull downs and immunoprecipitations and
  • Western blotting

Resume

Jaap studied Medical Biology at the University of Amsterdam, followed by a PhD training in the lab of Dr. Peter Hordijk. He finished his thesis in May 2004 and continued his research life in the US. He did his post-doctoral training in the lab of Professor Keith Burridge at the University of North Carolina in Chapel Hill from July 2004 until July 2006. Currently, he works as an E. Dekker research fellow (Hartstichting) in the department of Molecular Cell Biology at Sanquin Research in Amsterdam, studying signalling pathways that are involved in transendothelial migration of leukocytes.