Willem (W. J. J.) Falkenburg MD

Structure & function of antibodies

Training

Medicine, Utrecht University

Research interests

My project focuses on improving the characterization of the rheumatoid factor response and other antibody-against-antibody responses in Rheumatoid Arthritis (RA). This will hopefully lead to better prediction of onset and course of the disease and add to our understanding of the role of antibody responses in the pathogenesis of RA.

Technology

  • ELISA
  • RIA
  • FACS

Resume

2013-present PhD student at Reade, Eular center of excellence in rheumatology and the Dept of Immunopathology, Sanquin Research
2013 Medical Resident, Tergooi Hospitals, Hilversum, division of Internal Medicine
2011-2012 Medical Resident, Haga Teaching Hospital, The Hague, division of Hematology
2011 Research Traineeship, Dept of Rheumatology and Clinical Immunology, University Medical Center, Utrecht
2010-2011 Sub-internship Cardiology, St. Antonius Hospital, Nieuwegein
2008-2009 Visiting Research Fellow, National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, USA
2008 Research Traineeship, Laboratory of Experimental Hematology, Leiden University Medical Center, Leiden

Other publications

Nieuwenhuizen L, Falkenburg WJ, Schutgens RE, Roosendaal G, van Veghel K, Biesma DH, Lafeber FP. Stimulation of naïve monocytes and PBMCs with coagulation proteases results in thrombin-mediated and PAR-1-dependent cytokine release and cell proliferation in PBMCs only. Scand J Immunol 2013; 77(5):339-49.

Falkenburg WJ, Melenhorst JJ, van de Meent M, Kester MG, Hombrink P, Heemskerk MH, Hagedoorn RS, Gostick E, Price DA, Falkenburg JH, Barrett AJ, Jedema I. Allogeneic HLA-A2-restricted WT1-specific T cells from mismatched donors are highly reactive but show off-target promiscuity. J Immunol 2011; 187(5):2824-33.