Ilse (I) Jongerius PhD


Complement, molecular microbiology and immunology


Complement evasion of Staphylococcus aureus
Department of Medical Microbiology, UMCU, NL
Promotor: Prof. J.A.G. van Strijp
Co-promotor: Dr. S.H.M. Rooijakkers


Research interests

My research focus and interest have always been the complement system. First, I have studied infection and immunity with emphasis on the complement system and  bacterial evasion. I have investigated the role in complement during bacterial infection and especially the mechanisms that bacterial employ to evade the complement system. The use of bacterial complement evasion molecules has given us important insights in the human complement system during infection, but was also used to crystalize important complement components.

To date, my research interest is shifting towards the role of complement in health and disease.  With a specific focus on factor H, the Factor H-related (FHR) proteins and C1 esterase inhibitor (C1-INH). I aim to unravel the functional role of FH and FHR proteins in health and disease. Next, I aim to use a complement evasion molecule to unravel the exact mechanism of action of C1-INH.


  • Cell culture
  • Flow Cytometry
  • Molecular biology techniques
  • Complement assays


2018-present Group leader Complement Research Department of Immunopathology, Sanquin, Amsterdam, NL
2014-2017 Assistant professor Department of Medical Microbiology, University Medical Center Utrecht (UMCU), NL
2013-2017 Post-doctoral researcher National Institute for Public Health and the Environment (RIVM), Center for Immunology of Infectious Diseases and Vaccines, NL
2010-2013 Rubicon fellow Sir William Dunn School of Pathology, Oxford University, UK, MCR Centre for Molecular Bacteriology and Infection, Imperial College, London, UK

Other activities



  • 2014: VENI – NWO ZonMw (personal grant)
  • 2012: Meningitidis UK – co-applicant
  • 2010: NWO Rubicon – NWO ZonMw/ALW (personal grant)
  • 2010: EMBO Long-Term Fellowship – (personal grant)