Dieke (D. J.) van Rees


MSc Biomedical Sciences; Immunology and Infectious diseases

Research interests

This project aims to characterize SIRPα-CD47 interactions during antibody-mediated killing of tumor cells by neutrophils. The ubiquitously expressed CD47 is often upregulated on tumor cells, and serves as a ‘don’t kill me’ or signal for immune cells. Signal-regulatory protein (SIRP) α on myeloid cells, including macrophages and neutrophils, binds to CD47 and this interaction results in an inhibitory signal. We will explore how interfering with SIRPα-CD47 interactions promote antibody-mediated cancer cells destruction and we will also investigate the potential for therapeutic targeting of this interaction.


  • Flow cytometry
  • Confocal microscopy
  • Blood cell isolation
  • Phagocytosis assay


2015-present PhD student at Dept Blood Cell Research, Sanquin Research, Amsterdam, The Netherlands
2012-2014 Master Biomedical Sciences, VU, Amsterdam
2007-2011 Bachelor Life Sciences, Saxion, Deventer

Other publications